null
SMILES: C[C@@H]1Cc2cc3c(cc(=O)[nH]c3cc2N1)C(F)(F)F
InChI Key: InChIKey=UDMCMALCRGIISA-ZCFIWIBFSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Androgen receptor (Homo sapiens (Human)) | BDBM50069068 ((R)-2-Methyl-5-trifluoromethyl-1,2,3,8-tetrahydro-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals Curated by ChEMBL | Assay Description Binding affinity against Androgen receptor transfected into COS cells | Bioorg Med Chem Lett 8: 745-50 (1999) BindingDB Entry DOI: 10.7270/Q2XS5THG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mineralocorticoid receptor (Homo sapiens (Human)) | BDBM50069068 ((R)-2-Methyl-5-trifluoromethyl-1,2,3,8-tetrahydro-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals Curated by ChEMBL | Assay Description Antagonistic activity against hMR in cotransfected CV-1 cell | Bioorg Med Chem Lett 8: 745-50 (1999) BindingDB Entry DOI: 10.7270/Q2XS5THG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM50069068 ((R)-2-Methyl-5-trifluoromethyl-1,2,3,8-tetrahydro-...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals Curated by ChEMBL | Assay Description Antagonistic activity against Glucocorticoid receptor in cotransfected CV-1 cell | Bioorg Med Chem Lett 8: 745-50 (1999) BindingDB Entry DOI: 10.7270/Q2XS5THG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen receptor (Homo sapiens (Human)) | BDBM50069068 ((R)-2-Methyl-5-trifluoromethyl-1,2,3,8-tetrahydro-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals Curated by ChEMBL | Assay Description Antagonistic activity (IC50) against human androgen receptor (hAR) in cotransfected CV-1 cell | Bioorg Med Chem Lett 8: 745-50 (1999) BindingDB Entry DOI: 10.7270/Q2XS5THG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor beta (Homo sapiens (Human)) | BDBM50069068 ((R)-2-Methyl-5-trifluoromethyl-1,2,3,8-tetrahydro-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals Curated by ChEMBL | Assay Description Antagonistic activity against Estrogen receptor in co-transfected CV-1 cell | Bioorg Med Chem Lett 8: 745-50 (1999) BindingDB Entry DOI: 10.7270/Q2XS5THG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen receptor (Homo sapiens (Human)) | BDBM50069068 ((R)-2-Methyl-5-trifluoromethyl-1,2,3,8-tetrahydro-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 168 | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals Curated by ChEMBL | Assay Description Agonistic activity (EC50) against human androgen receptor (hAR) in cotransfected CV-1 cell | Bioorg Med Chem Lett 8: 745-50 (1999) BindingDB Entry DOI: 10.7270/Q2XS5THG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Progesterone receptor (Homo sapiens (Human)) | BDBM50069068 ((R)-2-Methyl-5-trifluoromethyl-1,2,3,8-tetrahydro-...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 750 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals Curated by ChEMBL | Assay Description Antagonistic activity against hPR in cotransfected CV-1 cell | Bioorg Med Chem Lett 8: 745-50 (1999) BindingDB Entry DOI: 10.7270/Q2XS5THG | |||||||||||
More data for this Ligand-Target Pair |