BDBM50069254 3-Benzhydrylidene-1-{3-[4-(2-methoxy-phenyl)-piperazin-1-yl]-propyl}-pyrrolidine-2,5-dione::CHEMBL147954
SMILES: [#6]-[#8]-c1ccccc1-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-[#6]-[#7]-2-[#6](=O)-[#6]\[#6](=[#6](/c3ccccc3)-c3ccccc3)-[#6]-2=O)-[#6]-[#6]-1
InChI Key: InChIKey=FGEIPEJHLJEOQZ-UHFFFAOYSA-N
Data: 5 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50069254![]() (3-Benzhydrylidene-1-{3-[4-(2-methoxy-phenyl)-piper...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | 8.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad Complutense Curated by ChEMBL | Assay Description In vitro binding affinity against Alpha-1 adrenergic receptor in rat cerebral cortex membrane using [3H]prazosin as radioligand | Bioorg Med Chem Lett 8: 581-6 (1999) BindingDB Entry DOI: 10.7270/Q2N878XB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50069254![]() (3-Benzhydrylidene-1-{3-[4-(2-methoxy-phenyl)-piper...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | 156 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad Complutense Curated by ChEMBL | Assay Description In vitro binding affinity against Dopamine receptor D2 in rat striatum membrane using [3H]-raclopride as radioligand | Bioorg Med Chem Lett 8: 581-6 (1999) BindingDB Entry DOI: 10.7270/Q2N878XB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50069254![]() (3-Benzhydrylidene-1-{3-[4-(2-methoxy-phenyl)-piper...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 156 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad Complutense Curated by ChEMBL | Assay Description In vitro binding affinity towards Dopamine receptor D2 of rat striatal membranes using [3H]- raclopride | J Med Chem 42: 36-49 (1999) Article DOI: 10.1021/jm980285e BindingDB Entry DOI: 10.7270/Q2B27TFT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat)) | BDBM50069254![]() (3-Benzhydrylidene-1-{3-[4-(2-methoxy-phenyl)-piper...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 665 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad Complutense Curated by ChEMBL | Assay Description Binding affinity at 5-hydroxytryptamine 1A (5-HT1A) receptor in rat cerebral cortex using [3H]-8-OH-DPAT as radioligand | J Med Chem 42: 36-49 (1999) Article DOI: 10.1021/jm980285e BindingDB Entry DOI: 10.7270/Q2B27TFT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat)) | BDBM50069254![]() (3-Benzhydrylidene-1-{3-[4-(2-methoxy-phenyl)-piper...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | 665 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad Complutense Curated by ChEMBL | Assay Description In vitro binding affinity against serotonin 5-HT1A receptor in rat cerebral cortex membrane using [3H]-8-OH-DPAT as radioligand | Bioorg Med Chem Lett 8: 581-6 (1999) BindingDB Entry DOI: 10.7270/Q2N878XB | |||||||||||
More data for this Ligand-Target Pair |