BDBM50069368 (R)-6-(3-(1-((1-(carboxymethyl)cyclopropyl)methylthio)-3-(2-(2-hydroxypropan-2-yl)phenyl)propyl)styryl)nicotinic acid::6-[(E)-2-(3-{(R)-1-(1-Carboxymethyl-cyclopropylmethylsulfanyl)-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propyl}-phenyl)-vinyl]-nicotinic acid::CHEMBL141300
SMILES: CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(O)=O)CC1)c1cccc(\C=C\c2ccc(cn2)C(O)=O)c1
InChI Key: InChIKey=JXVXKIYLTSMUSV-OXIVNLASSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cysteinyl leukotriene receptor (Homo sapiens (Human)) | BDBM50069368 ((R)-6-(3-(1-((1-(carboxymethyl)cyclopropyl)methylt...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 421 | n/a | n/a | n/a | n/a | n/a | n/a |
Zhejiang University Curated by ChEMBL | Assay Description Antagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before L... | Bioorg Med Chem 18: 5519-27 (2010) Article DOI: 10.1016/j.bmc.2010.06.047 BindingDB Entry DOI: 10.7270/Q26D5TZ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cysteinyl leukotriene receptor (Homo sapiens (Human)) | BDBM50069368 ((R)-6-(3-(1-((1-(carboxymethyl)cyclopropyl)methylt...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 421 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Center for Therapeutic Research Curated by ChEMBL | Assay Description In vitro inhibition of [3H]-LTD4 binding to LTD4 receptor of guinea pig lung membrane without human serum albumin (HSA). | Bioorg Med Chem Lett 8: 453-8 (1999) BindingDB Entry DOI: 10.7270/Q2M907SH | |||||||||||
More data for this Ligand-Target Pair |