BDBM50070879 CHEMBL299521::Sodium; (Z)-2-benzo[1,2,5]thiadiazol-5-yl-3-(3-fluoro-4-methoxy-benzyl)-4-(4-methoxy-phenyl)-4-oxo-but-2-enoate
SMILES: COc1ccc(cc1)C(=O)C(\Cc1ccc(OC)c(F)c1)=C(/C([O-])=O)c1ccc2nsnc2c1
InChI Key: InChIKey=WPTYOJVFRZMDBQ-NKFKGCMQSA-M
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
EDNRA (RAT) | BDBM50070879 (CHEMBL299521 | Sodium; (Z)-2-benzo[1,2,5]thiadiazo...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck KGaA Curated by ChEMBL | Assay Description In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor | Bioorg Med Chem Lett 8: 1771-6 (1999) BindingDB Entry DOI: 10.7270/Q2TM7BM4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelin receptor ET-B (Sus scrofa) | BDBM50070879 (CHEMBL299521 | Sodium; (Z)-2-benzo[1,2,5]thiadiazo...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 2.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck KGaA Curated by ChEMBL | Assay Description In vitro ability to inhibit specific [125I]ET1 binding to porcine kidney (inner medulla) membranes Endothelin B receptor | Bioorg Med Chem Lett 8: 1771-6 (1999) BindingDB Entry DOI: 10.7270/Q2TM7BM4 | |||||||||||
More data for this Ligand-Target Pair |