BDBM50071702 1-[4-(8-Chloro-5,11-dihydro-10-thia-4-aza-dibenzo[a,d]cyclohepten-5-yl)-piperazin-1-yl]-2-pyridin-4-yl-ethanone::CHEMBL430450

SMILES: Clc1ccc2C(N3CCN(CC3)C(=O)Cc3ccncc3)c3ncccc3CSc2c1

InChI Key: InChIKey=WQCCHVJLXWFMBZ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50071702   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50071702 (1-[4-(8-Chloro-5,11-dihydro-10-thia-4-aza-dibenzo[...) Show SMILES Clc1ccc2C(N3CCN(CC3)C(=O)Cc3ccncc3)c3ncccc3CSc2c1 Show InChI InChI=1S/C24H23ClN4OS/c25-19-3-4-20-21(15-19)31-16-18-2-1-7-27-23(18)24(20)29-12-10-28(11-13-29)22(30)14-17-5-8-26-9-6-17/h1-9,15,24H,10-14,16H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description In vitro FPT potency by measuring the ability to inhibit the transfer of [3H]-farnesyl from farnesyl pyrophosphate to H-Ras-CLVS.				Bioorg Med Chem Lett 8: 2521-6 (1999) BindingDB Entry DOI: 10.7270/Q24M93PP
					More data for this Ligand-Target Pair
Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50071702 (1-[4-(8-Chloro-5,11-dihydro-10-thia-4-aza-dibenzo[...) Show SMILES Clc1ccc2C(N3CCN(CC3)C(=O)Cc3ccncc3)c3ncccc3CSc2c1 Show InChI InChI=1S/C24H23ClN4OS/c25-19-3-4-20-21(15-19)31-16-18-2-1-7-27-23(18)24(20)29-12-10-28(11-13-29)22(30)14-17-5-8-26-9-6-17/h1-9,15,24H,10-14,16H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description In vitro FPT potency by measuring the ability to inhibit the transfer of [3H]-farnesyl from farnesyl pyrophosphate to H-Ras-CLVS.				Bioorg Med Chem Lett 8: 2521-6 (1999) BindingDB Entry DOI: 10.7270/Q24M93PP
					More data for this Ligand-Target Pair