BDBM50071703 CHEMBL311434::Cyanoguanidine derivative

SMILES: [#8-]-[n+]1cccc(-[#6]-[#7]-[#6](=[#7]C#N)-[#7]-2-[#6]-[#6]\[#6](-[#6]-[#6]-2)=[#6]-2/c3ccc(Cl)cc3-[#16]-[#6]-c3cccnc-23)c1

InChI Key: InChIKey=HASNIZLQJKWUHP-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50071703   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50071703 (CHEMBL311434 | Cyanoguanidine derivative) Show SMILES [#8-]-[n+]1cccc(-[#6]-[#7]-[#6](=[#7]C#N)-[#7]-2-[#6]-[#6]\[#6](-[#6]-[#6]-2)=[#6]-2/c3ccc(Cl)cc3-[#16]-[#6]-c3cccnc-23)c1 |w:9.9| Show InChI InChI=1S/C26H23ClN6OS/c27-21-5-6-22-23(13-21)35-16-20-4-1-9-29-25(20)24(22)19-7-11-32(12-8-19)26(31-17-28)30-14-18-3-2-10-33(34)15-18/h1-6,9-10,13,15H,7-8,11-12,14,16H2,(H,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description In vitro FPT potency by measuring the ability to inhibit the transfer of [3H]-farnesyl from farnesyl pyrophosphate to H-Ras-CLVS.				Bioorg Med Chem Lett 8: 2521-6 (1999) BindingDB Entry DOI: 10.7270/Q24M93PP
					More data for this Ligand-Target Pair