BDBM50071704 4-{2-[4-(8-Chloro-5,11-dihydro-10-thia-4-aza-dibenzo[a,d]cyclohepten-5-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid amide::CHEMBL85663

SMILES: NC(=O)N1CCC(CC(=O)N2CCN(CC2)C2c3ccc(Cl)cc3SCc3cccnc23)CC1

InChI Key: InChIKey=MPAJJFCONLAFJJ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50071704   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50071704 (4-{2-[4-(8-Chloro-5,11-dihydro-10-thia-4-aza-diben...) Show SMILES NC(=O)N1CCC(CC(=O)N2CCN(CC2)C2c3ccc(Cl)cc3SCc3cccnc23)CC1 Show InChI InChI=1S/C25H30ClN5O2S/c26-19-3-4-20-21(15-19)34-16-18-2-1-7-28-23(18)24(20)30-12-10-29(11-13-30)22(32)14-17-5-8-31(9-6-17)25(27)33/h1-4,7,15,17,24H,5-6,8-14,16H2,(H2,27,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.12E+3	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description In vitro FPT potency by measuring the ability to inhibit the transfer of [3H]-farnesyl from farnesyl pyrophosphate to H-Ras-CLVS.				Bioorg Med Chem Lett 8: 2521-6 (1999) BindingDB Entry DOI: 10.7270/Q24M93PP
					More data for this Ligand-Target Pair