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BDBM50071706 1-[4-(8-Chloro-11H-10-thia-4-aza-dibenzo[a,d]cyclohepten-5-ylidene)-piperidin-1-yl]-2-(1-methyl-piperidin-4-yl)-ethanone::CHEMBL85671

SMILES: [#6]-[#7]-1-[#6]-[#6]-[#6](-[#6]-[#6](=O)-[#7]-2-[#6]-[#6]\[#6](-[#6]-[#6]-2)=[#6]-2/c3ccc(Cl)cc3-[#16]-[#6]-c3cccnc-23)-[#6]-[#6]-1

InChI Key: InChIKey=UNQXNXZNETUFGG-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50071706   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))		BDBM50071706
PNG
(1-[4-(8-Chloro-11H-10-thia-4-aza-dibenzo[a,d]cyclo...)
Show SMILES [#6]-[#7]-1-[#6]-[#6]-[#6](-[#6]-[#6](=O)-[#7]-2-[#6]-[#6]\[#6](-[#6]-[#6]-2)=[#6]-2/c3ccc(Cl)cc3-[#16]-[#6]-c3cccnc-23)-[#6]-[#6]-1
Show InChI InChI=1S/C26H30ClN3OS/c1-29-11-6-18(7-12-29)15-24(31)30-13-8-19(9-14-30)25-22-5-4-21(27)16-23(22)32-17-20-3-2-10-28-26(20)25/h2-5,10,16,18H,6-9,11-15,17H2,1H3
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PubMed
n/an/a 1.79E+3n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
In vitro FPT potency by measuring the ability to inhibit the transfer of [3H]-farnesyl from farnesyl pyrophosphate to H-Ras-CLVS.

Bioorg Med Chem Lett 8: 2521-6 (1999)


BindingDB Entry DOI: 10.7270/Q24M93PP
More data for this
Ligand-Target Pair