BDBM50071707 1-[4-(8-Chloro-5,11-dihydro-10-thia-4-aza-dibenzo[a,d]cyclohepten-5-yl)-piperazin-1-yl]-2-(1-methyl-piperidin-4-yl)-ethanone::CHEMBL85529

SMILES: CN1CCC(CC(=O)N2CCN(CC2)C2c3ccc(Cl)cc3SCc3cccnc23)CC1

InChI Key: InChIKey=RLDKSMWNRZTDIS-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50071707   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50071707 (1-[4-(8-Chloro-5,11-dihydro-10-thia-4-aza-dibenzo[...) Show SMILES CN1CCC(CC(=O)N2CCN(CC2)C2c3ccc(Cl)cc3SCc3cccnc23)CC1 Show InChI InChI=1S/C25H31ClN4OS/c1-28-9-6-18(7-10-28)15-23(31)29-11-13-30(14-12-29)25-21-5-4-20(26)16-22(21)32-17-19-3-2-8-27-24(19)25/h2-5,8,16,18,25H,6-7,9-15,17H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description In vitro FPT potency by measuring the ability to inhibit the transfer of [3H]-farnesyl from farnesyl pyrophosphate to H-Ras-CLVS.				Bioorg Med Chem Lett 8: 2521-6 (1999) BindingDB Entry DOI: 10.7270/Q24M93PP
					More data for this Ligand-Target Pair