BDBM50071709 CHEMBL87345::Cyanoguanidine derivative

SMILES: CN1Cc2cccnc2C(N2CCN(CC2)C(NCc2ccncc2)=NC#N)c2ccc(Cl)cc12

InChI Key: InChIKey=ZMAIYSCOFUTXQH-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50071709   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50071709 (CHEMBL87345 | Cyanoguanidine derivative) Show SMILES CN1Cc2cccnc2C(N2CCN(CC2)C(NCc2ccncc2)=NC#N)c2ccc(Cl)cc12 |w:25.28| Show InChI InChI=1S/C26H27ClN8/c1-33-17-20-3-2-8-30-24(20)25(22-5-4-21(27)15-23(22)33)34-11-13-35(14-12-34)26(32-18-28)31-16-19-6-9-29-10-7-19/h2-10,15,25H,11-14,16-17H2,1H3,(H,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description In vitro FPT potency by measuring the ability to inhibit the transfer of [3H]-farnesyl from farnesyl pyrophosphate to H-Ras-CLVS.				Bioorg Med Chem Lett 8: 2521-6 (1999) BindingDB Entry DOI: 10.7270/Q24M93PP
					More data for this Ligand-Target Pair