BDBM50071710 1-[4-(8-Chloro-5,11-dihydro-10-thia-4-aza-dibenzo[a,d]cyclohepten-5-yl)-piperazin-1-yl]-2-(1-oxy-pyridin-4-yl)-ethanone::CHEMBL423677
SMILES: [O-][n+]1ccc(CC(=O)N2CCN(CC2)C2c3ccc(Cl)cc3SCc3cccnc23)cc1
InChI Key: InChIKey=UBHOMARBJHLMPA-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Protein Farnesyltransferase (PFT) (Homo sapiens (Human)) | BDBM50071710 (1-[4-(8-Chloro-5,11-dihydro-10-thia-4-aza-dibenzo[...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 79 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute Curated by ChEMBL | Assay Description In vitro FPT potency by measuring the ability to inhibit the transfer of [3H]-farnesyl from farnesyl pyrophosphate to H-Ras-CLVS. | Bioorg Med Chem Lett 8: 2521-6 (1999) BindingDB Entry DOI: 10.7270/Q24M93PP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Farnesyltransferase (PFT) (Homo sapiens (Human)) | BDBM50071710 (1-[4-(8-Chloro-5,11-dihydro-10-thia-4-aza-dibenzo[...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute Curated by ChEMBL | Assay Description In vitro inhibition of Ras processing in COS cells | Bioorg Med Chem Lett 8: 2521-6 (1999) BindingDB Entry DOI: 10.7270/Q24M93PP | |||||||||||
More data for this Ligand-Target Pair |