BDBM50072427 1-(1-(2-(isopropyl(phenyl)amino)-2-oxoethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-3-phenylurea::2-[2,4-Dioxo-5-phenyl-3-(3-phenyl-ureido)-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl]-N-isopropyl-N-phenyl-acetamide::CHEMBL321761
SMILES: CC(C)N(C(=O)CN1c2ccccc2N(c2ccccc2)C(=O)C(NC(=O)Nc2ccccc2)C1=O)c1ccccc1
InChI Key: InChIKey=ITMJPTIFWLPIOL-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cholecystokinin receptor (Homo sapiens (Human)) | BDBM50072427 (1-(1-(2-(isopropyl(phenyl)amino)-2-oxoethyl)-2,4-d...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Roche Products Ltd Curated by ChEMBL | Assay Description Tested for the 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecy... | Bioorg Med Chem Lett 7: 429-32 (1997) Article DOI: 10.1016/S0960-894X(97)00062-0 BindingDB Entry DOI: 10.7270/Q2DJ5G4B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholecystokinin receptor (Homo sapiens (Human)) | BDBM50072427 (1-(1-(2-(isopropyl(phenyl)amino)-2-oxoethyl)-2,4-d...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Roche Products Ltd Curated by ChEMBL | Assay Description Tested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystok... | Bioorg Med Chem Lett 7: 429-32 (1997) Article DOI: 10.1016/S0960-894X(97)00062-0 BindingDB Entry DOI: 10.7270/Q2DJ5G4B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholecystokinin receptor (RAT) | BDBM50072427 (1-(1-(2-(isopropyl(phenyl)amino)-2-oxoethyl)-2,4-d...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurogen Corporation Curated by ChEMBL | Assay Description Displacement of 125I]-D-Tyr-Gly-[(Nle28,31)CCK-26-33] from rat cell membrane Cholecystokinin type A receptor | Bioorg Med Chem Lett 8: 3127-32 (1999) BindingDB Entry DOI: 10.7270/Q2VD6ZZX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholecystokinin receptor (Homo sapiens (Human)) | BDBM50072427 (1-(1-(2-(isopropyl(phenyl)amino)-2-oxoethyl)-2,4-d...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development Curated by ChEMBL | Assay Description Binding affinity against human Cholecystokinin type A receptor in membrane preparation isolated from CHO-K1 cells stably transfected with cDNA of hum... | J Med Chem 39: 3030-4 (1996) Article DOI: 10.1021/jm960205b BindingDB Entry DOI: 10.7270/Q26H4JPR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholecystokinin receptor (Homo sapiens (Human)) | BDBM50072427 (1-(1-(2-(isopropyl(phenyl)amino)-2-oxoethyl)-2,4-d...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a |
Roche Products Ltd Curated by ChEMBL | Assay Description Concentration of compound that induced 50% of the maximal contraction in guinea pig gallbladder tissue when tested in vitro | Bioorg Med Chem Lett 7: 429-32 (1997) Article DOI: 10.1016/S0960-894X(97)00062-0 BindingDB Entry DOI: 10.7270/Q2DJ5G4B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholecystokinin receptor (Homo sapiens (Human)) | BDBM50072427 (1-(1-(2-(isopropyl(phenyl)amino)-2-oxoethyl)-2,4-d...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Curated by ChEMBL | Assay Description Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type A receptor stably expressed in CHO-K1 cells | J Med Chem 39: 562-9 (1996) Article DOI: 10.1021/jm950626d BindingDB Entry DOI: 10.7270/Q22R3SZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholecystokinin receptor (Homo sapiens (Human)) | BDBM50072427 (1-(1-(2-(isopropyl(phenyl)amino)-2-oxoethyl)-2,4-d...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Curated by ChEMBL | Assay Description Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cells | J Med Chem 39: 562-9 (1996) Article DOI: 10.1021/jm950626d BindingDB Entry DOI: 10.7270/Q22R3SZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholecystokinin receptor (Homo sapiens (Human)) | BDBM50072427 (1-(1-(2-(isopropyl(phenyl)amino)-2-oxoethyl)-2,4-d...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development Curated by ChEMBL | Assay Description Compound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transf... | J Med Chem 39: 5236-45 (1997) Article DOI: 10.1021/jm9601664 BindingDB Entry DOI: 10.7270/Q2PG1T0Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholecystokinin receptor (Homo sapiens (Human)) | BDBM50072427 (1-(1-(2-(isopropyl(phenyl)amino)-2-oxoethyl)-2,4-d...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development Curated by ChEMBL | Assay Description Compound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transf... | J Med Chem 39: 5236-45 (1997) Article DOI: 10.1021/jm9601664 BindingDB Entry DOI: 10.7270/Q2PG1T0Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholecystokinin receptor (Homo sapiens (Human)) | BDBM50072427 (1-(1-(2-(isopropyl(phenyl)amino)-2-oxoethyl)-2,4-d...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development Curated by ChEMBL | Assay Description Binding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligand | J Med Chem 39: 3030-4 (1996) Article DOI: 10.1021/jm960205b BindingDB Entry DOI: 10.7270/Q26H4JPR | |||||||||||
More data for this Ligand-Target Pair |