BDBM50072700 2,2,4-Trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene::2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f]quinoline::CHEMBL67362

SMILES: CC1=CC(C)(C)Nc2ccc-3c(COc4ccccc-34)c12

InChI Key: InChIKey=CNWLUDPVYBPOSX-UHFFFAOYSA-N

Data: 3 KI  1 IC50  4 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50072700   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Progesterone receptor (Homo sapiens (Human))	BDBM50072700 (2,2,4-Trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysen...) Show SMILES CC1=CC(C)(C)Nc2ccc-3c(COc4ccccc-34)c12 |t:1| Show InChI InChI=1S/C19H19NO/c1-12-10-19(2,3)20-16-9-8-13-14-6-4-5-7-17(14)21-11-15(13)18(12)16/h4-10,20H,11H2,1-3H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	83	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Scientific Computing Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]progesterone from Progesterone receptor				J Med Chem 49: 4261-8 (2006) Article DOI: 10.1021/jm060234e BindingDB Entry DOI: 10.7270/Q2V69NB6
					More data for this Ligand-Target Pair
Progesterone receptor (Homo sapiens (Human))	BDBM50072700 (2,2,4-Trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysen...) Show SMILES CC1=CC(C)(C)Nc2ccc-3c(COc4ccccc-34)c12 |t:1| Show InChI InChI=1S/C19H19NO/c1-12-10-19(2,3)20-16-9-8-13-14-6-4-5-7-17(14)21-11-15(13)18(12)16/h4-10,20H,11H2,1-3H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	84	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of human progesterone receptor activation in T47D human breast cancer cell.				Bioorg Med Chem Lett 13: 2075-8 (2003) BindingDB Entry DOI: 10.7270/Q2P55P2M
					More data for this Ligand-Target Pair
Progesterone receptor (Homo sapiens (Human))	BDBM50072700 (2,2,4-Trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysen...) Show SMILES CC1=CC(C)(C)Nc2ccc-3c(COc4ccccc-34)c12 |t:1| Show InChI InChI=1S/C19H19NO/c1-12-10-19(2,3)20-16-9-8-13-14-6-4-5-7-17(14)21-11-15(13)18(12)16/h4-10,20H,11H2,1-3H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	84	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Binding affinity was determined against hPR-A (human progesterone receptor) using progesterone radioligand in competitive binding assay				Bioorg Med Chem Lett 8: 3365-70 (1999) BindingDB Entry DOI: 10.7270/Q2BC402X
					More data for this Ligand-Target Pair
Progesterone receptor (Homo sapiens (Human))	BDBM50072700 (2,2,4-Trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysen...) Show SMILES CC1=CC(C)(C)Nc2ccc-3c(COc4ccccc-34)c12 |t:1| Show InChI InChI=1S/C19H19NO/c1-12-10-19(2,3)20-16-9-8-13-14-6-4-5-7-17(14)21-11-15(13)18(12)16/h4-10,20H,11H2,1-3H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of human progesterone receptor activation in T47D human breast cancer cell.				Bioorg Med Chem Lett 13: 2075-8 (2003) BindingDB Entry DOI: 10.7270/Q2P55P2M
					More data for this Ligand-Target Pair
Progesterone receptor (Homo sapiens (Human))	BDBM50072700 (2,2,4-Trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysen...) Show SMILES CC1=CC(C)(C)Nc2ccc-3c(COc4ccccc-34)c12 |t:1| Show InChI InChI=1S/C19H19NO/c1-12-10-19(2,3)20-16-9-8-13-14-6-4-5-7-17(14)21-11-15(13)18(12)16/h4-10,20H,11H2,1-3H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	111	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals Curated by ChEMBL					Assay Description Antagonistic activity at human progesterone receptor in CV-1 cells.				Bioorg Med Chem Lett 13: 2075-8 (2003) BindingDB Entry DOI: 10.7270/Q2P55P2M
					More data for this Ligand-Target Pair
Progesterone receptor (Homo sapiens (Human))	BDBM50072700 (2,2,4-Trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysen...) Show SMILES CC1=CC(C)(C)Nc2ccc-3c(COc4ccccc-34)c12 |t:1| Show InChI InChI=1S/C19H19NO/c1-12-10-19(2,3)20-16-9-8-13-14-6-4-5-7-17(14)21-11-15(13)18(12)16/h4-10,20H,11H2,1-3H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	71	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Antagonist activity against hPR (human progesterone receptor) compared to that of progesterone (100%)				Bioorg Med Chem Lett 8: 3365-70 (1999) BindingDB Entry DOI: 10.7270/Q2BC402X
					More data for this Ligand-Target Pair
Progesterone receptor (Homo sapiens (Human))	BDBM50072700 (2,2,4-Trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysen...) Show SMILES CC1=CC(C)(C)Nc2ccc-3c(COc4ccccc-34)c12 |t:1| Show InChI InChI=1S/C19H19NO/c1-12-10-19(2,3)20-16-9-8-13-14-6-4-5-7-17(14)21-11-15(13)18(12)16/h4-10,20H,11H2,1-3H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	138	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of human progesterone receptor activation in T47D human breast cancer cell.				Bioorg Med Chem Lett 13: 2075-8 (2003) BindingDB Entry DOI: 10.7270/Q2P55P2M
					More data for this Ligand-Target Pair
Progesterone receptor (Homo sapiens (Human))	BDBM50072700 (2,2,4-Trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysen...) Show SMILES CC1=CC(C)(C)Nc2ccc-3c(COc4ccccc-34)c12 |t:1| Show InChI InChI=1S/C19H19NO/c1-12-10-19(2,3)20-16-9-8-13-14-6-4-5-7-17(14)21-11-15(13)18(12)16/h4-10,20H,11H2,1-3H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	3.08E+3	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Binding affinity was determined against hPR-A (human progesterone receptor) using progesterone radioligand in competitive binding assay				Bioorg Med Chem Lett 8: 3365-70 (1999) BindingDB Entry DOI: 10.7270/Q2BC402X
					More data for this Ligand-Target Pair