BDBM50072712 8-Fluoro-5-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene::CHEMBL333167

SMILES: COC1Oc2cc(F)ccc2-c2ccc3NC(C)(C)C=C(C)c3c12

InChI Key: InChIKey=DEHOTNIOLAUDNF-UHFFFAOYSA-N

Data: 1 KI  2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50072712   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Progesterone receptor (Homo sapiens (Human))	BDBM50072712 (8-Fluoro-5-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-...) Show SMILES COC1Oc2cc(F)ccc2-c2ccc3NC(C)(C)C=C(C)c3c12 |t:20| Show InChI InChI=1S/C20H20FNO2/c1-11-10-20(2,3)22-15-8-7-14-13-6-5-12(21)9-16(13)24-19(23-4)18(14)17(11)15/h5-10,19,22H,1-4H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	81	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Antagonist activity against hPR (human progesterone receptor) compared to that of progesterone (100%)				Bioorg Med Chem Lett 8: 3365-70 (1999) BindingDB Entry DOI: 10.7270/Q2BC402X
					More data for this Ligand-Target Pair
Progesterone receptor (Homo sapiens (Human))	BDBM50072712 (8-Fluoro-5-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-...) Show SMILES COC1Oc2cc(F)ccc2-c2ccc3NC(C)(C)C=C(C)c3c12 |t:20| Show InChI InChI=1S/C20H20FNO2/c1-11-10-20(2,3)22-15-8-7-14-13-6-5-12(21)9-16(13)24-19(23-4)18(14)17(11)15/h5-10,19,22H,1-4H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Agonist activity was determined against hPR (human progesterone receptor) compared to that of progesterone (100%)				Bioorg Med Chem Lett 8: 3365-70 (1999) BindingDB Entry DOI: 10.7270/Q2BC402X
					More data for this Ligand-Target Pair
Progesterone receptor (Homo sapiens (Human))	BDBM50072712 (8-Fluoro-5-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-...) Show SMILES COC1Oc2cc(F)ccc2-c2ccc3NC(C)(C)C=C(C)c3c12 |t:20| Show InChI InChI=1S/C20H20FNO2/c1-11-10-20(2,3)22-15-8-7-14-13-6-5-12(21)9-16(13)24-19(23-4)18(14)17(11)15/h5-10,19,22H,1-4H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	49	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Antagonist activity against hPR (human progesterone receptor) compared to that of progesterone (100%)				Bioorg Med Chem Lett 8: 3365-70 (1999) BindingDB Entry DOI: 10.7270/Q2BC402X
					More data for this Ligand-Target Pair