BDBM50074193 3-{3-[4-(2-Pyridin-3-yl-ethyl)-piperazin-1-yl]-propyl}-5-[1,2,4]triazol-4-yl-1H-indole::CHEMBL351311

SMILES: C(CN1CCN(CCc2cccnc2)CC1)Cc1c[nH]c2ccc(cc12)-n1cnnc1

InChI Key: InChIKey=FCBBVPHMCOPHEA-UHFFFAOYSA-N

Data: 2 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50074193   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-hydroxytryptamine receptor 1D (Homo sapiens (Human))	BDBM50074193 (3-{3-[4-(2-Pyridin-3-yl-ethyl)-piperazin-1-yl]-pro...) Show SMILES C(CN1CCN(CCc2cccnc2)CC1)Cc1c[nH]c2ccc(cc12)-n1cnnc1 Show InChI InChI=1S/C24H29N7/c1-3-20(16-25-8-1)7-10-30-13-11-29(12-14-30)9-2-4-21-17-26-24-6-5-22(15-23(21)24)31-18-27-28-19-31/h1,3,5-6,8,15-19,26H,2,4,7,9-14H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.90	n/a	n/a	n/a	n/a	n/a	n/a
Merck, Sharp and Dohme Research Laboratories Curated by ChEMBL					Assay Description Displacement of [3H]-5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells				J Med Chem 42: 691-705 (1999) Article DOI: 10.1021/jm980569z BindingDB Entry DOI: 10.7270/Q2ZG6RDW
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1D (Homo sapiens (Human))	BDBM50074193 (3-{3-[4-(2-Pyridin-3-yl-ethyl)-piperazin-1-yl]-pro...) Show SMILES C(CN1CCN(CCc2cccnc2)CC1)Cc1c[nH]c2ccc(cc12)-n1cnnc1 Show InChI InChI=1S/C24H29N7/c1-3-20(16-25-8-1)7-10-30-13-11-29(12-14-30)9-2-4-21-17-26-24-6-5-22(15-23(21)24)31-18-27-28-19-31/h1,3,5-6,8,15-19,26H,2,4,7,9-14H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	7.80	n/a	n/a	n/a	n/a
Merck, Sharp and Dohme Research Laboratories Curated by ChEMBL					Assay Description Stimulation of [35S]-GTP-gammaS, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.				J Med Chem 42: 691-705 (1999) Article DOI: 10.1021/jm980569z BindingDB Entry DOI: 10.7270/Q2ZG6RDW
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1B (Homo sapiens (Human))	BDBM50074193 (3-{3-[4-(2-Pyridin-3-yl-ethyl)-piperazin-1-yl]-pro...) Show SMILES C(CN1CCN(CCc2cccnc2)CC1)Cc1c[nH]c2ccc(cc12)-n1cnnc1 Show InChI InChI=1S/C24H29N7/c1-3-20(16-25-8-1)7-10-30-13-11-29(12-14-30)9-2-4-21-17-26-24-6-5-22(15-23(21)24)31-18-27-28-19-31/h1,3,5-6,8,15-19,26H,2,4,7,9-14H2	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	93	n/a	n/a	n/a	n/a	n/a	n/a
Merck, Sharp and Dohme Research Laboratories Curated by ChEMBL					Assay Description Displacement of [3H]-5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.				J Med Chem 42: 691-705 (1999) Article DOI: 10.1021/jm980569z BindingDB Entry DOI: 10.7270/Q2ZG6RDW
					More data for this Ligand-Target Pair