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BDBM50074742 CHEMBL7866::[3-(3-Chloro-phenyl)-5-hydroxy-7-methoxy-4-oxo-4H-quinolin-1-yl]-acetic acid methyl ester

SMILES: COC(=O)Cn1cc(-c2cccc(Cl)c2)c(=O)c2c(O)cc(OC)cc12

InChI Key: InChIKey=CXCSYLLGUQWHHQ-UHFFFAOYSA-N

Data: 7 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50074742   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50074742
PNG
(CHEMBL7866 | [3-(3-Chloro-phenyl)-5-hydroxy-7-meth...)
Show SMILES COC(=O)Cn1cc(-c2cccc(Cl)c2)c(=O)c2c(O)cc(OC)cc12
Show InChI InChI=1S/C19H16ClNO5/c1-25-13-7-15-18(16(22)8-13)19(24)14(9-21(15)10-17(23)26-2)11-4-3-5-12(20)6-11/h3-9,22H,10H2,1-2H3
PDB
MMDB

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n/an/a>1.00E+5n/an/an/an/an/an/a



NOVARTIS Limited

Curated by ChEMBL


Assay Description
Inhibition of Protein kinase C alpha


J Med Chem 42: 1018-26 (1999)


Article DOI: 10.1021/jm980551o
BindingDB Entry DOI: 10.7270/Q21835PV
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50074742
PNG
(CHEMBL7866 | [3-(3-Chloro-phenyl)-5-hydroxy-7-meth...)
Show SMILES COC(=O)Cn1cc(-c2cccc(Cl)c2)c(=O)c2c(O)cc(OC)cc12
Show InChI InChI=1S/C19H16ClNO5/c1-25-13-7-15-18(16(22)8-13)19(24)14(9-21(15)10-17(23)26-2)11-4-3-5-12(20)6-11/h3-9,22H,10H2,1-2H3
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n/an/a 64n/an/an/an/an/an/a



NOVARTIS Limited

Curated by ChEMBL


Assay Description
Inhibition of Epidermal growth factor receptor


J Med Chem 42: 1018-26 (1999)


Article DOI: 10.1021/jm980551o
BindingDB Entry DOI: 10.7270/Q21835PV
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1/ABL2


(Homo sapiens (Human))
BDBM50074742
PNG
(CHEMBL7866 | [3-(3-Chloro-phenyl)-5-hydroxy-7-meth...)
Show SMILES COC(=O)Cn1cc(-c2cccc(Cl)c2)c(=O)c2c(O)cc(OC)cc12
Show InChI InChI=1S/C19H16ClNO5/c1-25-13-7-15-18(16(22)8-13)19(24)14(9-21(15)10-17(23)26-2)11-4-3-5-12(20)6-11/h3-9,22H,10H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



NOVARTIS Limited

Curated by ChEMBL


Assay Description
Inhibition of v-Abl tyrosine kinase


J Med Chem 42: 1018-26 (1999)


Article DOI: 10.1021/jm980551o
BindingDB Entry DOI: 10.7270/Q21835PV
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Mus musculus)
BDBM50074742
PNG
(CHEMBL7866 | [3-(3-Chloro-phenyl)-5-hydroxy-7-meth...)
Show SMILES COC(=O)Cn1cc(-c2cccc(Cl)c2)c(=O)c2c(O)cc(OC)cc12
Show InChI InChI=1S/C19H16ClNO5/c1-25-13-7-15-18(16(22)8-13)19(24)14(9-21(15)10-17(23)26-2)11-4-3-5-12(20)6-11/h3-9,22H,10H2,1-2H3
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n/an/a 9.55E+3n/an/an/an/an/an/a



NOVARTIS Limited

Curated by ChEMBL


Assay Description
Inhibition of EGF-dependent mouse keratinocyte MK cell proliferation


J Med Chem 42: 1018-26 (1999)


Article DOI: 10.1021/jm980551o
BindingDB Entry DOI: 10.7270/Q21835PV
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50074742
PNG
(CHEMBL7866 | [3-(3-Chloro-phenyl)-5-hydroxy-7-meth...)
Show SMILES COC(=O)Cn1cc(-c2cccc(Cl)c2)c(=O)c2c(O)cc(OC)cc12
Show InChI InChI=1S/C19H16ClNO5/c1-25-13-7-15-18(16(22)8-13)19(24)14(9-21(15)10-17(23)26-2)11-4-3-5-12(20)6-11/h3-9,22H,10H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



NOVARTIS Limited

Curated by ChEMBL


Assay Description
Inhibition of p60 c-Src tyrosine kinase


J Med Chem 42: 1018-26 (1999)


Article DOI: 10.1021/jm980551o
BindingDB Entry DOI: 10.7270/Q21835PV
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50074742
PNG
(CHEMBL7866 | [3-(3-Chloro-phenyl)-5-hydroxy-7-meth...)
Show SMILES COC(=O)Cn1cc(-c2cccc(Cl)c2)c(=O)c2c(O)cc(OC)cc12
Show InChI InChI=1S/C19H16ClNO5/c1-25-13-7-15-18(16(22)8-13)19(24)14(9-21(15)10-17(23)26-2)11-4-3-5-12(20)6-11/h3-9,22H,10H2,1-2H3
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PubMed
n/an/a 1.25E+4n/an/an/an/an/an/a



NOVARTIS Limited

Curated by ChEMBL


Assay Description
Inhibition of Epidermal growth factor receptor-dependent phosphorylation


J Med Chem 42: 1018-26 (1999)


Article DOI: 10.1021/jm980551o
BindingDB Entry DOI: 10.7270/Q21835PV
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))
BDBM50074742
PNG
(CHEMBL7866 | [3-(3-Chloro-phenyl)-5-hydroxy-7-meth...)
Show SMILES COC(=O)Cn1cc(-c2cccc(Cl)c2)c(=O)c2c(O)cc(OC)cc12
Show InChI InChI=1S/C19H16ClNO5/c1-25-13-7-15-18(16(22)8-13)19(24)14(9-21(15)10-17(23)26-2)11-4-3-5-12(20)6-11/h3-9,22H,10H2,1-2H3
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



NOVARTIS Limited

Curated by ChEMBL


Assay Description
Inhibition of Platelet-derived growth factor receptor-dependent phosphorylation


J Med Chem 42: 1018-26 (1999)


Article DOI: 10.1021/jm980551o
BindingDB Entry DOI: 10.7270/Q21835PV
More data for this
Ligand-Target Pair