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SMILES: CCOc1ccccc1-c1cc([nH]c1-c1ccncc1)-c1ccc(Cl)cc1

InChI Key: InChIKey=MDNFXHVVRABLPD-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50075754   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glucagon receptor (Mus musculus)	BDBM50075754 (4-[5-(4-Chloro-phenyl)-3-(2-ethoxy-phenyl)-1H-pyrr...) Show SMILES CCOc1ccccc1-c1cc([nH]c1-c1ccncc1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C23H19ClN2O/c1-2-27-22-6-4-3-5-19(22)20-15-21(16-7-9-18(24)10-8-16)26-23(20)17-11-13-25-14-12-17/h3-15,26H,2H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	340	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards glucagon receptor determined by reduction in binding of [125I]-glucagon to the murine glucagon receptor (GGR) expressed on C...				Bioorg Med Chem Lett 9: 641-6 (1999) BindingDB Entry DOI: 10.7270/Q2VD6XM1
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50075754 (4-[5-(4-Chloro-phenyl)-3-(2-ethoxy-phenyl)-1H-pyrr...) Show SMILES CCOc1ccccc1-c1cc([nH]c1-c1ccncc1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C23H19ClN2O/c1-2-27-22-6-4-3-5-19(22)20-15-21(16-7-9-18(24)10-8-16)26-23(20)17-11-13-25-14-12-17/h3-15,26H,2H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.42E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against p38-alpha kinase				Bioorg Med Chem Lett 9: 641-6 (1999) BindingDB Entry DOI: 10.7270/Q2VD6XM1
					More data for this Ligand-Target Pair
Glucagon receptor (Homo sapiens (Human))	BDBM50075754 (4-[5-(4-Chloro-phenyl)-3-(2-ethoxy-phenyl)-1H-pyrr...) Show SMILES CCOc1ccccc1-c1cc([nH]c1-c1ccncc1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C23H19ClN2O/c1-2-27-22-6-4-3-5-19(22)20-15-21(16-7-9-18(24)10-8-16)26-23(20)17-11-13-25-14-12-17/h3-15,26H,2H2,1H3	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	1.42E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist activity at human glucagon receptor				Citation and Details Article DOI: 10.1007/s00044-013-0801-3 BindingDB Entry DOI: 10.7270/Q20G3MM3
					More data for this Ligand-Target Pair
Glucagon receptor (Homo sapiens (Human))	BDBM50075754 (4-[5-(4-Chloro-phenyl)-3-(2-ethoxy-phenyl)-1H-pyrr...) Show SMILES CCOc1ccccc1-c1cc([nH]c1-c1ccncc1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C23H19ClN2O/c1-2-27-22-6-4-3-5-19(22)20-15-21(16-7-9-18(24)10-8-16)26-23(20)17-11-13-25-14-12-17/h3-15,26H,2H2,1H3	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards glucagon receptor determined by reduction in binding of [125I]-glucagon to the human glucagon receptor (GGR) expressed on CH...				Bioorg Med Chem Lett 9: 641-6 (1999) BindingDB Entry DOI: 10.7270/Q2VD6XM1
					More data for this Ligand-Target Pair
Glucagon receptor (Homo sapiens (Human))	BDBM50075754 (4-[5-(4-Chloro-phenyl)-3-(2-ethoxy-phenyl)-1H-pyrr...) Show SMILES CCOc1ccccc1-c1cc([nH]c1-c1ccncc1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C23H19ClN2O/c1-2-27-22-6-4-3-5-19(22)20-15-21(16-7-9-18(24)10-8-16)26-23(20)17-11-13-25-14-12-17/h3-15,26H,2H2,1H3	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Binding affinity determined by reduction in binding of 125 I-glucagon to the human glucagon receptor expressed on CHO cells in absence of Mg+2				Bioorg Med Chem Lett 9: 641-6 (1999) BindingDB Entry DOI: 10.7270/Q2VD6XM1
					More data for this Ligand-Target Pair