BDBM50076145 (S)-4-Methyl-2-{2-naphthalen-1-yl-4-[(pyridin-4-ylmethyl)-amino]-benzoylamino}-pentanoic acid::CHEMBL282814

SMILES: CC(C)C[C@H](NC(=O)c1ccc(NCc2ccncc2)cc1-c1cccc2ccccc12)C(O)=O

InChI Key: InChIKey=UPLOQONPZIFQRI-MHZLTWQESA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50076145   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Farnesyltransferase (PFT) Chain B (Homo sapiens (Human))	BDBM50076145 ((S)-4-Methyl-2-{2-naphthalen-1-yl-4-[(pyridin-4-yl...) Show SMILES CC(C)C[C@H](NC(=O)c1ccc(NCc2ccncc2)cc1-c1cccc2ccccc12)C(O)=O Show InChI InChI=1S/C29H29N3O3/c1-19(2)16-27(29(34)35)32-28(33)25-11-10-22(31-18-20-12-14-30-15-13-20)17-26(25)24-9-5-7-21-6-3-4-8-23(21)24/h3-15,17,19,27,31H,16,18H2,1-2H3,(H,32,33)(H,34,35)/t27-/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Yale University Curated by ChEMBL					Assay Description In vitro inhibition of [3H]-FPP incorporation into H-Ras-CVLS by Farnesyl transferase				J Med Chem 42: 1333-40 (1999) Article DOI: 10.1021/jm9900873 BindingDB Entry DOI: 10.7270/Q28G8JW7
					More data for this Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50076145 ((S)-4-Methyl-2-{2-naphthalen-1-yl-4-[(pyridin-4-yl...) Show SMILES CC(C)C[C@H](NC(=O)c1ccc(NCc2ccncc2)cc1-c1cccc2ccccc12)C(O)=O Show InChI InChI=1S/C29H29N3O3/c1-19(2)16-27(29(34)35)32-28(33)25-11-10-22(31-18-20-12-14-30-15-13-20)17-26(25)24-9-5-7-21-6-3-4-8-23(21)24/h3-15,17,19,27,31H,16,18H2,1-2H3,(H,32,33)(H,34,35)/t27-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Yale University Curated by ChEMBL					Assay Description In vitro inhibition of [3H]-GGPP incorporation into H-Ras-CVLL by Geranylgeranyl transferase type I				J Med Chem 42: 1333-40 (1999) Article DOI: 10.1021/jm9900873 BindingDB Entry DOI: 10.7270/Q28G8JW7
					More data for this Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit (Mus musculus)	BDBM50076145 ((S)-4-Methyl-2-{2-naphthalen-1-yl-4-[(pyridin-4-yl...) Show SMILES CC(C)C[C@H](NC(=O)c1ccc(NCc2ccncc2)cc1-c1cccc2ccccc12)C(O)=O Show InChI InChI=1S/C29H29N3O3/c1-19(2)16-27(29(34)35)32-28(33)25-11-10-22(31-18-20-12-14-30-15-13-20)17-26(25)24-9-5-7-21-6-3-4-8-23(21)24/h3-15,17,19,27,31H,16,18H2,1-2H3,(H,32,33)(H,34,35)/t27-/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Yale University Curated by ChEMBL					Assay Description In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing.				J Med Chem 42: 1333-40 (1999) Article DOI: 10.1021/jm9900873 BindingDB Entry DOI: 10.7270/Q28G8JW7
					More data for this Ligand-Target Pair