BDBM50077536 (S)-1-(1,2,3,4-Tetrahydro-isoquinolin-3-yl)-methanol::CHEMBL61489
SMILES: OC[C@@H]1Cc2ccccc2CN1
InChI Key: InChIKey=ZSKDXMLMMQFHGW-JTQLQIEISA-N
Data: 4 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Phenylethanolamine N-methyltransferase (Bos taurus (bovine)) | BDBM50077536![]() ((S)-1-(1,2,3,4-Tetrahydro-isoquinolin-3-yl)-methan...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | 7.99E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas Curated by ChEMBL | Assay Description Inhibitory activity against bovine adrenal phenylethanolamine N-methyl-transferase (PNMT) | Bioorg Med Chem Lett 9: 481-6 (1999) BindingDB Entry DOI: 10.7270/Q26Q20F9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor (RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50077536![]() ((S)-1-(1,2,3,4-Tetrahydro-isoquinolin-3-yl)-methan...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | 8.48E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas Curated by ChEMBL | Assay Description Inhibition of [3H]clonidine binding to the rat alpha-2-adrenoceptor | Bioorg Med Chem Lett 9: 481-6 (1999) BindingDB Entry DOI: 10.7270/Q26Q20F9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phenylethanolamine N-methyltransferase (Bos taurus (bovine)) | BDBM50077536![]() ((S)-1-(1,2,3,4-Tetrahydro-isoquinolin-3-yl)-methan...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas Curated by ChEMBL | Assay Description Inhibition of bovine adrenal Phenylethanolamine N-Methyltransferase | J Med Chem 42: 1982-90 (1999) Article DOI: 10.1021/jm9807252 BindingDB Entry DOI: 10.7270/Q2959GR6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phenylethanolamine N-methyltransferase (Bos taurus (bovine)) | BDBM50077536![]() ((S)-1-(1,2,3,4-Tetrahydro-isoquinolin-3-yl)-methan...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | 1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas Curated by ChEMBL | Assay Description In vitro inhibition of PNMT (Phenylethanolamine N-Methyltransferase). | J Med Chem 42: 4351-61 (1999) BindingDB Entry DOI: 10.7270/Q2X0667W | |||||||||||
More data for this Ligand-Target Pair |