BDBM50078929 (2-{N-[1-Carbamoyl-2-(1H-indol-3-yl)-ethyl]-hydrazinocarbonyl}-5-phenyl-pentyl)-{1-[2-(5-chloro-2-hydroxy-phenylamino)-acetylamino]-2-phenyl-ethyl}-phosphinic acid::CHEMBL405651

SMILES: NN(C(Cc1c[nH]c2ccccc12)C(N)=O)C(=O)C(CCCc1ccccc1)CP(O)(=O)C(Cc1ccccc1)NC(=O)CNc1cc(Cl)ccc1O

InChI Key: InChIKey=WUXSSALNWBMRKU-UHFFFAOYSA-N

Data: 5 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50078929   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Neutrophil collagenase (Homo sapiens (Human))	BDBM50078929 ((2-{N-[1-Carbamoyl-2-(1H-indol-3-yl)-ethyl]-hydraz...) Show SMILES NN(C(Cc1c[nH]c2ccccc12)C(N)=O)C(=O)C(CCCc1ccccc1)CP(O)(=O)C(Cc1ccccc1)NC(=O)CNc1cc(Cl)ccc1O Show InChI InChI=1S/C39H44ClN6O6P/c40-30-18-19-35(47)33(22-30)44-24-36(48)45-37(20-27-12-5-2-6-13-27)53(51,52)25-28(15-9-14-26-10-3-1-4-11-26)39(50)46(42)34(38(41)49)21-29-23-43-32-17-8-7-16-31(29)32/h1-8,10-13,16-19,22-23,28,34,37,43-44,47H,9,14-15,20-21,24-25,42H2,(H2,41,49)(H,45,48)(H,51,52)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	7.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
CEA Curated by ChEMBL					Assay Description Inhibition of matrix metalloprotease-8				J Med Chem 42: 2610-20 (1999) Article DOI: 10.1021/jm9900164 BindingDB Entry DOI: 10.7270/Q22B8X71
					More data for this Ligand-Target Pair
Matrix metalloproteinase 11 (Mus musculus)	BDBM50078929 ((2-{N-[1-Carbamoyl-2-(1H-indol-3-yl)-ethyl]-hydraz...) Show SMILES NN(C(Cc1c[nH]c2ccccc12)C(N)=O)C(=O)C(CCCc1ccccc1)CP(O)(=O)C(Cc1ccccc1)NC(=O)CNc1cc(Cl)ccc1O Show InChI InChI=1S/C39H44ClN6O6P/c40-30-18-19-35(47)33(22-30)44-24-36(48)45-37(20-27-12-5-2-6-13-27)53(51,52)25-28(15-9-14-26-10-3-1-4-11-26)39(50)46(42)34(38(41)49)21-29-23-43-32-17-8-7-16-31(29)32/h1-8,10-13,16-19,22-23,28,34,37,43-44,47H,9,14-15,20-21,24-25,42H2,(H2,41,49)(H,45,48)(H,51,52)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
CEA Curated by ChEMBL					Assay Description Binding affinity against matrix metalloprotease-11.				J Med Chem 42: 2610-20 (1999) Article DOI: 10.1021/jm9900164 BindingDB Entry DOI: 10.7270/Q22B8X71
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50078929 ((2-{N-[1-Carbamoyl-2-(1H-indol-3-yl)-ethyl]-hydraz...) Show SMILES NN(C(Cc1c[nH]c2ccccc12)C(N)=O)C(=O)C(CCCc1ccccc1)CP(O)(=O)C(Cc1ccccc1)NC(=O)CNc1cc(Cl)ccc1O Show InChI InChI=1S/C39H44ClN6O6P/c40-30-18-19-35(47)33(22-30)44-24-36(48)45-37(20-27-12-5-2-6-13-27)53(51,52)25-28(15-9-14-26-10-3-1-4-11-26)39(50)46(42)34(38(41)49)21-29-23-43-32-17-8-7-16-31(29)32/h1-8,10-13,16-19,22-23,28,34,37,43-44,47H,9,14-15,20-21,24-25,42H2,(H2,41,49)(H,45,48)(H,51,52)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
CEA Curated by ChEMBL					Assay Description Binding affinity against matrix metalloprotease-2 (gelatinase-A).				J Med Chem 42: 2610-20 (1999) Article DOI: 10.1021/jm9900164 BindingDB Entry DOI: 10.7270/Q22B8X71
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50078929 ((2-{N-[1-Carbamoyl-2-(1H-indol-3-yl)-ethyl]-hydraz...) Show SMILES NN(C(Cc1c[nH]c2ccccc12)C(N)=O)C(=O)C(CCCc1ccccc1)CP(O)(=O)C(Cc1ccccc1)NC(=O)CNc1cc(Cl)ccc1O Show InChI InChI=1S/C39H44ClN6O6P/c40-30-18-19-35(47)33(22-30)44-24-36(48)45-37(20-27-12-5-2-6-13-27)53(51,52)25-28(15-9-14-26-10-3-1-4-11-26)39(50)46(42)34(38(41)49)21-29-23-43-32-17-8-7-16-31(29)32/h1-8,10-13,16-19,22-23,28,34,37,43-44,47H,9,14-15,20-21,24-25,42H2,(H2,41,49)(H,45,48)(H,51,52)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	44	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
CEA Curated by ChEMBL					Assay Description Binding affinity against matrix metalloprotease-9 (gelatinase-B).				J Med Chem 42: 2610-20 (1999) Article DOI: 10.1021/jm9900164 BindingDB Entry DOI: 10.7270/Q22B8X71
					More data for this Ligand-Target Pair
Matrix metalloproteinase-14 (MMP14) (Homo sapiens (Human))	BDBM50078929 ((2-{N-[1-Carbamoyl-2-(1H-indol-3-yl)-ethyl]-hydraz...) Show SMILES NN(C(Cc1c[nH]c2ccccc12)C(N)=O)C(=O)C(CCCc1ccccc1)CP(O)(=O)C(Cc1ccccc1)NC(=O)CNc1cc(Cl)ccc1O Show InChI InChI=1S/C39H44ClN6O6P/c40-30-18-19-35(47)33(22-30)44-24-36(48)45-37(20-27-12-5-2-6-13-27)53(51,52)25-28(15-9-14-26-10-3-1-4-11-26)39(50)46(42)34(38(41)49)21-29-23-43-32-17-8-7-16-31(29)32/h1-8,10-13,16-19,22-23,28,34,37,43-44,47H,9,14-15,20-21,24-25,42H2,(H2,41,49)(H,45,48)(H,51,52)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	63	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
CEA Curated by ChEMBL					Assay Description Binding affinity against matrix metalloprotease-14 MTI-MMP.				J Med Chem 42: 2610-20 (1999) Article DOI: 10.1021/jm9900164 BindingDB Entry DOI: 10.7270/Q22B8X71
					More data for this Ligand-Target Pair