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SMILES: COc1ccc(CN(Cc2cnc[nH]2)Cc2cccc(c2)C(=O)N[C@@H](CCSC)C(O)=O)cc1

InChI Key: InChIKey=XJNQXVWYAHPYPM-QHCPKHFHSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50079672   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50079672
PNG
((S)-2-(3-{[(1H-Imidazol-4-ylmethyl)-(4-methoxy-ben...)
Show SMILES COc1ccc(CN(Cc2cnc[nH]2)Cc2cccc(c2)C(=O)N[C@@H](CCSC)C(O)=O)cc1
Show InChI InChI=1S/C25H30N4O4S/c1-33-22-8-6-18(7-9-22)14-29(16-21-13-26-17-27-21)15-19-4-3-5-20(12-19)24(30)28-23(25(31)32)10-11-34-2/h3-9,12-13,17,23H,10-11,14-16H2,1-2H3,(H,26,27)(H,28,30)(H,31,32)/t23-/m0/s1
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n/an/a 355n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Reduction in the FTase-catalyzed (enzyme purified from bovine brain) incorporation of [3H]-FPP into recombinant Ha-Ras.

Bioorg Med Chem Lett 9: 1991-6 (1999)


BindingDB Entry DOI: 10.7270/Q2ZG6RFB
More data for this
Ligand-Target Pair