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SMILES: Cc1ccccc1\C(=N\OCCN1CCC[C@@H](C1)C(O)=O)c1cccc(Cl)c1

InChI Key: InChIKey=WWRSXMGYAVUUNM-QAYQYMSWSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50080338   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium- and chloride-dependent GABA transporter 1


(Rattus norvegicus)		BDBM50080338
PNG
((S)-1-{2-[1-(3-Chloro-phenyl)-1-o-tolyl-meth-(E)-y...)
Show SMILES Cc1ccccc1\C(=N\OCCN1CCC[C@@H](C1)C(O)=O)c1cccc(Cl)c1
Show InChI InChI=1S/C22H25ClN2O3/c1-16-6-2-3-10-20(16)21(17-7-4-9-19(23)14-17)24-28-13-12-25-11-5-8-18(15-25)22(26)27/h2-4,6-7,9-10,14,18H,5,8,11-13,15H2,1H3,(H,26,27)/b24-21+/t18-/m0/s1
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Similars
Article
PubMed
 93n/an/an/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]GABA uptake at the Sodium- and chloride-dependent GABA transporter 1 (GAT-1) uptake site in rat brain synaptosomes

J Med Chem 42: 3447-62 (1999)


Article DOI: 10.1021/jm981027k
BindingDB Entry DOI: 10.7270/Q2057GMV
More data for this
Ligand-Target Pair