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SMILES: [#8]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#6]-[#7](-[#6]-[#6]-[#8]\[#6]=[#6](/c2ccc(F)cc2F)-c2ccc(F)cc2F)-[#6]-1

InChI Key: InChIKey=NJLUBEXPODTEMU-CQSZACIVSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50080361   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium- and chloride-dependent GABA transporter 1


(Rattus norvegicus)		BDBM50080361
PNG
((R)-1-{2-[2,2-Bis-(2,4-difluoro-phenyl)-vinyloxy]-...)
Show SMILES [#8]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#6]-[#7](-[#6]-[#6]-[#8]\[#6]=[#6](/c2ccc(F)cc2F)-c2ccc(F)cc2F)-[#6]-1
Show InChI InChI=1S/C22H21F4NO3/c23-15-3-5-17(20(25)10-15)19(18-6-4-16(24)11-21(18)26)13-30-9-8-27-7-1-2-14(12-27)22(28)29/h3-6,10-11,13-14H,1-2,7-9,12H2,(H,28,29)/t14-/m1/s1
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Article
PubMed
 132n/an/an/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]GABA uptake at the Sodium- and chloride-dependent GABA transporter 1 (GAT-1) uptake site in rat brain synaptosomes

J Med Chem 42: 3447-62 (1999)


Article DOI: 10.1021/jm981027k
BindingDB Entry DOI: 10.7270/Q2057GMV
More data for this
Ligand-Target Pair