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BDBM50080382 (R)-1-{2-[(Z)-2-(2-Chloro-phenyl)-2-o-tolyl-vinyloxy]-ethyl}-piperidine-3-carboxylic acid; hydrochloride::CHEMBL545511

SMILES: Cc1ccccc1\C(=C\OCCN1CCC[C@H](C1)C(O)=O)c1ccccc1Cl

InChI Key: InChIKey=RKYFXNMQSNFWLQ-TVJQZGFISA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50080382   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium- and chloride-dependent GABA transporter 1


(Rattus norvegicus)		BDBM50080382
PNG
((R)-1-{2-[(Z)-2-(2-Chloro-phenyl)-2-o-tolyl-vinylo...)
Show SMILES Cc1ccccc1\C(=C\OCCN1CCC[C@H](C1)C(O)=O)c1ccccc1Cl
Show InChI InChI=1S/C23H26ClNO3/c1-17-7-2-3-9-19(17)21(20-10-4-5-11-22(20)24)16-28-14-13-25-12-6-8-18(15-25)23(26)27/h2-5,7,9-11,16,18H,6,8,12-15H2,1H3,(H,26,27)/b21-16-/t18-/m1/s1
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Similars
Article
PubMed
 12n/an/an/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]GABA uptake at the Sodium- and chloride-dependent GABA transporter 1 (GAT-1) uptake site in rat brain synaptosomes

J Med Chem 42: 3447-62 (1999)


Article DOI: 10.1021/jm981027k
BindingDB Entry DOI: 10.7270/Q2057GMV
More data for this
Ligand-Target Pair