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BDBM50085195 2-{Cyclohexyl-[4-(4-phenyl-thiazol-2-ylmethoxy)-phenyl]-methoxyimino}-propionic acid (0.5H2O)::CHEMBL161830

SMILES: C\C(=N/OC(C1CCCCC1)c1ccc(OCc2nc(cs2)-c2ccccc2)cc1)C(O)=O

InChI Key: InChIKey=VFUYXLYPZOUDSL-MTDXEUNCSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50085195   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))		BDBM50085195
PNG
(2-{Cyclohexyl-[4-(4-phenyl-thiazol-2-ylmethoxy)-ph...)
Show SMILES C\C(=N/OC(C1CCCCC1)c1ccc(OCc2nc(cs2)-c2ccccc2)cc1)C(O)=O
Show InChI InChI=1S/C26H28N2O4S/c1-18(26(29)30)28-32-25(20-10-6-3-7-11-20)21-12-14-22(15-13-21)31-16-24-27-23(17-33-24)19-8-4-2-5-9-19/h2,4-5,8-9,12-15,17,20,25H,3,6-7,10-11,16H2,1H3,(H,29,30)/b28-18+
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n/an/a 20n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of calcium ionophore (A-23187)-stimulated LTB4 formation in human neutrophil assay

J Med Chem 43: 690-705 (2000)


BindingDB Entry DOI: 10.7270/Q2HD7WCR
More data for this
Ligand-Target Pair