BDBM50086553 6-(4-Bromo-thiophen-2-yl)-2,2,4-trimethyl-1,2-dihydro-quinoline::6-(4-bromothiophen-2-yl)-2,2,4-trimethyl-1,2-dihydroquinoline::CHEMBL538158

SMILES: CC1=CC(C)(C)Nc2ccc(cc12)-c1cc(Br)cs1

InChI Key: InChIKey=QRGCGNOXVSPDPZ-UHFFFAOYSA-N

Data: 2 KI  2 IC50  2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50086553   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Progesterone receptor (Homo sapiens (Human))	BDBM50086553 (6-(4-Bromo-thiophen-2-yl)-2,2,4-trimethyl-1,2-dihy...) Show SMILES CC1=CC(C)(C)Nc2ccc(cc12)-c1cc(Br)cs1 |t:1| Show InChI InChI=1S/C16H16BrNS/c1-10-8-16(2,3)18-14-5-4-11(6-13(10)14)15-7-12(17)9-19-15/h4-9,18H,1-3H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	32	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Scientific Computing Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]progesterone from Progesterone receptor				J Med Chem 49: 4261-8 (2006) Article DOI: 10.1021/jm060234e BindingDB Entry DOI: 10.7270/Q2V69NB6
					More data for this Ligand-Target Pair
Progesterone receptor (Homo sapiens (Human))	BDBM50086553 (6-(4-Bromo-thiophen-2-yl)-2,2,4-trimethyl-1,2-dihy...) Show SMILES CC1=CC(C)(C)Nc2ccc(cc12)-c1cc(Br)cs1 |t:1| Show InChI InChI=1S/C16H16BrNS/c1-10-8-16(2,3)18-14-5-4-11(6-13(10)14)15-7-12(17)9-19-15/h4-9,18H,1-3H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	32	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals Curated by ChEMBL					Assay Description Binding affinity against human progesterone receptor (hPR) in a competitive binding assay				Bioorg Med Chem Lett 10: 415-8 (2000) BindingDB Entry DOI: 10.7270/Q2P26ZMF
					More data for this Ligand-Target Pair
Progesterone receptor (Homo sapiens (Human))	BDBM50086553 (6-(4-Bromo-thiophen-2-yl)-2,2,4-trimethyl-1,2-dihy...) Show SMILES CC1=CC(C)(C)Nc2ccc(cc12)-c1cc(Br)cs1 |t:1| Show InChI InChI=1S/C16H16BrNS/c1-10-8-16(2,3)18-14-5-4-11(6-13(10)14)15-7-12(17)9-19-15/h4-9,18H,1-3H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals Curated by ChEMBL					Assay Description Human progesterone receptor (hPR) agonist activity in T47D human breast cancer cell line				Bioorg Med Chem Lett 10: 415-8 (2000) BindingDB Entry DOI: 10.7270/Q2P26ZMF
					More data for this Ligand-Target Pair
Progesterone receptor (Homo sapiens (Human))	BDBM50086553 (6-(4-Bromo-thiophen-2-yl)-2,2,4-trimethyl-1,2-dihy...) Show SMILES CC1=CC(C)(C)Nc2ccc(cc12)-c1cc(Br)cs1 |t:1| Show InChI InChI=1S/C16H16BrNS/c1-10-8-16(2,3)18-14-5-4-11(6-13(10)14)15-7-12(17)9-19-15/h4-9,18H,1-3H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals Curated by ChEMBL					Assay Description Antagonist activity against human progesterone receptor (hPR) using cotransfection assay in CV-1 cells				Bioorg Med Chem Lett 10: 415-8 (2000) BindingDB Entry DOI: 10.7270/Q2P26ZMF
					More data for this Ligand-Target Pair
Progesterone receptor (Homo sapiens (Human))	BDBM50086553 (6-(4-Bromo-thiophen-2-yl)-2,2,4-trimethyl-1,2-dihy...) Show SMILES CC1=CC(C)(C)Nc2ccc(cc12)-c1cc(Br)cs1 |t:1| Show InChI InChI=1S/C16H16BrNS/c1-10-8-16(2,3)18-14-5-4-11(6-13(10)14)15-7-12(17)9-19-15/h4-9,18H,1-3H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	105	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals Curated by ChEMBL					Assay Description Antagonist activity against human progesterone receptor (hPR) using cotransfection assay in CV-1 cells				Bioorg Med Chem Lett 10: 415-8 (2000) BindingDB Entry DOI: 10.7270/Q2P26ZMF
					More data for this Ligand-Target Pair
Progesterone receptor (Homo sapiens (Human))	BDBM50086553 (6-(4-Bromo-thiophen-2-yl)-2,2,4-trimethyl-1,2-dihy...) Show SMILES CC1=CC(C)(C)Nc2ccc(cc12)-c1cc(Br)cs1 |t:1| Show InChI InChI=1S/C16H16BrNS/c1-10-8-16(2,3)18-14-5-4-11(6-13(10)14)15-7-12(17)9-19-15/h4-9,18H,1-3H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals Curated by ChEMBL					Assay Description Human progesterone receptor (hPR) agonist activity expressed in CV-1 cells				Bioorg Med Chem Lett 10: 415-8 (2000) BindingDB Entry DOI: 10.7270/Q2P26ZMF
					More data for this Ligand-Target Pair