BDBM50088291 CHEMBL3427770
SMILES: CC1(C)CC(C(N)=O)c2[nH]nc(c2C1)-c1ccc(Cl)cc1
InChI Key: InChIKey=OKGNIDXKEISJOD-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
NAD-Dependent Deacetylase Sirtuin-1 (Homo sapiens (Human)) | BDBM50088291 (CHEMBL3427770) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc. Curated by ChEMBL | Assay Description Inhibition of His-tagged human recombinant SIRT1 expressed in Escherichia coli using Cbz-Lys(Ac)-AMC as substrate by fluorescence assay | Bioorg Med Chem Lett 25: 2514-8 (2015) Article DOI: 10.1016/j.bmcl.2015.04.068 BindingDB Entry DOI: 10.7270/Q2X63PN0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NAD-dependent deacetylase sirtuin 2 (Homo sapiens (Human)) | BDBM50088291 (CHEMBL3427770) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc. Curated by ChEMBL | Assay Description Inhibition of His-tagged human recombinant SIRT2 expressed in Escherichia coli using Cbz-Lys(Ac)-AMC as substrate by fluorescence assay | Bioorg Med Chem Lett 25: 2514-8 (2015) Article DOI: 10.1016/j.bmcl.2015.04.068 BindingDB Entry DOI: 10.7270/Q2X63PN0 | |||||||||||
More data for this Ligand-Target Pair |