BDBM50089901 2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid::2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid(S-HIBO)::CHEMBL88184

SMILES: N[C@@H](Cc1cc(=O)[nH]o1)C(O)=O

InChI Key: InChIKey=PEHXWVXZPICGAV-BYPYZUCNSA-N

Data: 8 KI  1 IC50  4 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50089901   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50089901 (2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...) Show SMILES N[C@@H](Cc1cc(=O)[nH]o1)C(O)=O Show InChI InChI=1S/C6H8N2O4/c7-4(6(10)11)1-3-2-5(9)8-12-3/h2,4H,1,7H2,(H,8,9)(H,10,11)/t4-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	2.50E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Agonist potency against cloned human metabotropic glutamate receptor 1				J Med Chem 43: 2609-45 (2000) BindingDB Entry DOI: 10.7270/Q2DZ090Q
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor (RAT)	BDBM50089901 (2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...) Show SMILES N[C@@H](Cc1cc(=O)[nH]o1)C(O)=O Show InChI InChI=1S/C6H8N2O4/c7-4(6(10)11)1-3-2-5(9)8-12-3/h2,4H,1,7H2,(H,8,9)(H,10,11)/t4-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	2.50E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description The compound was tested for the receptor binding affinity at Metabotropic glutamate receptor 1 using established second messenger assay systems.				J Med Chem 45: 988-91 (2002) BindingDB Entry DOI: 10.7270/Q2M32V27
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50089901 (2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...) Show SMILES N[C@@H](Cc1cc(=O)[nH]o1)C(O)=O Show InChI InChI=1S/C6H8N2O4/c7-4(6(10)11)1-3-2-5(9)8-12-3/h2,4H,1,7H2,(H,8,9)(H,10,11)/t4-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	4.90E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Agonist potency against cloned metabotropic glutamate receptor 5				J Med Chem 43: 2609-45 (2000) BindingDB Entry DOI: 10.7270/Q2DZ090Q
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor (Rattus norvegicus (Rat))	BDBM50089901 (2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...) Show SMILES N[C@@H](Cc1cc(=O)[nH]o1)C(O)=O Show InChI InChI=1S/C6H8N2O4/c7-4(6(10)11)1-3-2-5(9)8-12-3/h2,4H,1,7H2,(H,8,9)(H,10,11)/t4-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	4.90E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description The compound was tested for the receptor binding affinity at Metabotropic glutamate receptor 5 using established second messenger assay systems.				J Med Chem 45: 988-91 (2002) BindingDB Entry DOI: 10.7270/Q2M32V27
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4) (Homo sapiens (Human))	BDBM50089901 (2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...) Show SMILES N[C@@H](Cc1cc(=O)[nH]o1)C(O)=O Show InChI InChI=1S/C6H8N2O4/c7-4(6(10)11)1-3-2-5(9)8-12-3/h2,4H,1,7H2,(H,8,9)(H,10,11)/t4-/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Agonist potency against cloned human Metabotropic glutamate receptor 4 (mGluR-4)				J Med Chem 43: 2609-45 (2000) BindingDB Entry DOI: 10.7270/Q2DZ090Q
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4) (Rattus norvegicus (Rat))	BDBM50089901 (2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...) Show SMILES N[C@@H](Cc1cc(=O)[nH]o1)C(O)=O Show InChI InChI=1S/C6H8N2O4/c7-4(6(10)11)1-3-2-5(9)8-12-3/h2,4H,1,7H2,(H,8,9)(H,10,11)/t4-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description The compound was tested for the receptor binding affinity at Metabotropic glutamate receptor 4 using established second messenger assay systems.				J Med Chem 45: 988-91 (2002) BindingDB Entry DOI: 10.7270/Q2M32V27
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50089901 (2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...) Show SMILES N[C@@H](Cc1cc(=O)[nH]o1)C(O)=O Show InChI InChI=1S/C6H8N2O4/c7-4(6(10)11)1-3-2-5(9)8-12-3/h2,4H,1,7H2,(H,8,9)(H,10,11)/t4-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Antagonist potency against cloned Metabotropic glutamate receptor 2				J Med Chem 43: 2609-45 (2000) BindingDB Entry DOI: 10.7270/Q2DZ090Q
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50089901 (2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...) Show SMILES N[C@@H](Cc1cc(=O)[nH]o1)C(O)=O Show InChI InChI=1S/C6H8N2O4/c7-4(6(10)11)1-3-2-5(9)8-12-3/h2,4H,1,7H2,(H,8,9)(H,10,11)/t4-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description The compound was tested for the receptor binding affinity at Metabotropic glutamate receptor 2 using established second messenger assay systems.				J Med Chem 45: 988-91 (2002) BindingDB Entry DOI: 10.7270/Q2M32V27
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4) (Rattus norvegicus (Rat))	BDBM50089901 (2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...) Show SMILES N[C@@H](Cc1cc(=O)[nH]o1)C(O)=O Show InChI InChI=1S/C6H8N2O4/c7-4(6(10)11)1-3-2-5(9)8-12-3/h2,4H,1,7H2,(H,8,9)(H,10,11)/t4-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 4				J Med Chem 45: 4240-5 (2002) BindingDB Entry DOI: 10.7270/Q28G8K2W
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50089901 (2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...) Show SMILES N[C@@H](Cc1cc(=O)[nH]o1)C(O)=O Show InChI InChI=1S/C6H8N2O4/c7-4(6(10)11)1-3-2-5(9)8-12-3/h2,4H,1,7H2,(H,8,9)(H,10,11)/t4-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 2				J Med Chem 45: 4240-5 (2002) BindingDB Entry DOI: 10.7270/Q28G8K2W
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor (Rattus norvegicus (Rat))	BDBM50089901 (2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...) Show SMILES N[C@@H](Cc1cc(=O)[nH]o1)C(O)=O Show InChI InChI=1S/C6H8N2O4/c7-4(6(10)11)1-3-2-5(9)8-12-3/h2,4H,1,7H2,(H,8,9)(H,10,11)/t4-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	4.90E+5	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 5				J Med Chem 45: 4240-5 (2002) BindingDB Entry DOI: 10.7270/Q28G8K2W
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1 (RAT)	BDBM50089901 (2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...) Show SMILES N[C@@H](Cc1cc(=O)[nH]o1)C(O)=O Show InChI InChI=1S/C6H8N2O4/c7-4(6(10)11)1-3-2-5(9)8-12-3/h2,4H,1,7H2,(H,8,9)(H,10,11)/t4-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Concentration of the compound which causes 50% reduction in receptor binding affinity against Ionotropic glutamate receptor ionotropic kainate using ...				J Med Chem 45: 988-91 (2002) BindingDB Entry DOI: 10.7270/Q2M32V27
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor (RAT)	BDBM50089901 (2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...) Show SMILES N[C@@H](Cc1cc(=O)[nH]o1)C(O)=O Show InChI InChI=1S/C6H8N2O4/c7-4(6(10)11)1-3-2-5(9)8-12-3/h2,4H,1,7H2,(H,8,9)(H,10,11)/t4-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	2.50E+5	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 1				J Med Chem 45: 4240-5 (2002) BindingDB Entry DOI: 10.7270/Q28G8K2W
					More data for this Ligand-Target Pair