BDBM50092379 7-Bromo-1-(3H-imidazol-4-ylmethyl)-4-methanesulfonyl-3-(4-methoxy-benzyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine::CHEMBL439601
SMILES: COc1ccc(CC2CN(Cc3cnc[nH]3)c3ccc(Br)cc3CN2S(C)(=O)=O)cc1
InChI Key: InChIKey=KFKANIQRRNPYNQ-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Protein Farnesyltransferase (PFT) Chain B (Homo sapiens (Human)) | BDBM50092379 (7-Bromo-1-(3H-imidazol-4-ylmethyl)-4-methanesulfon...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 101 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of purified recombinant human farnesyltransferase (FT) | J Med Chem 43: 3587-95 (2000) BindingDB Entry DOI: 10.7270/Q2WD3ZSV | |||||||||||
More data for this Ligand-Target Pair |