BDBM50097076 4-[5-(2,3-Dioxo-4-phenyl-piperazin-1-ylmethyl)-imidazol-1-ylmethyl]-benzonitrile::CHEMBL356470
SMILES: O=C1N(Cc2cncn2Cc2ccc(cc2)C#N)CCN(C1=O)c1ccccc1
InChI Key: InChIKey=LSAYXMOAGAKDGT-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT) (Homo sapiens (Human)) | BDBM50097076 (4-[5-(2,3-Dioxo-4-phenyl-piperazin-1-ylmethyl)-imi...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Binding affinity towards 5-hydroxytryptamine 3 receptor | Bioorg Med Chem Lett 11: 537-40 (2001) BindingDB Entry DOI: 10.7270/Q2TT4Q7P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Farnesyltransferase (PFT) (Homo sapiens (Human)) | BDBM50097076 (4-[5-(2,3-Dioxo-4-phenyl-piperazin-1-ylmethyl)-imi...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of [3H]-FPP incorporation into recombinant Ras-CVIM by human farnesyl transferase | Bioorg Med Chem Lett 11: 537-40 (2001) BindingDB Entry DOI: 10.7270/Q2TT4Q7P | |||||||||||
More data for this Ligand-Target Pair |