BDBM50097081 4-{5-[4-(3-Chloro-phenyl)-2-oxo-piperazin-1-ylmethyl]-imidazol-1-ylmethyl}-benzonitrile::CHEMBL150449

SMILES: Clc1cccc(c1)N1CCN(Cc2cncn2Cc2ccc(cc2)C#N)C(=O)C1

InChI Key: InChIKey=WZMXYZAFOUYBRH-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50097081   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50097081 (4-{5-[4-(3-Chloro-phenyl)-2-oxo-piperazin-1-ylmeth...) Show SMILES Clc1cccc(c1)N1CCN(Cc2cncn2Cc2ccc(cc2)C#N)C(=O)C1 Show InChI InChI=1S/C22H20ClN5O/c23-19-2-1-3-20(10-19)26-8-9-27(22(29)15-26)14-21-12-25-16-28(21)13-18-6-4-17(11-24)5-7-18/h1-7,10,12,16H,8-9,13-15H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of [3H]-FPP incorporation into recombinant Ras-CVIM by human farnesyl transferase				Bioorg Med Chem Lett 11: 537-40 (2001) BindingDB Entry DOI: 10.7270/Q2TT4Q7P
					More data for this Ligand-Target Pair