BDBM50097798 CHEMBL163262::N-[5-((R)-2-{1-[4-(2,4-Dioxo-thiazolidin-5-ylmethyl)-phenyl]-piperidin-4-ylamino}-1-hydroxy-ethyl)-2-hydroxy-phenyl]-methanesulfonamide::N-[5-(2-{1-[4-((R)-2,4-Dioxo-thiazolidin-5-ylmethyl)-phenyl]-piperidin-4-ylamino}-1-hydroxy-ethyl)-2-hydroxy-phenyl]-methanesulfonamide
SMILES: CS(=O)(=O)Nc1cc(ccc1O)[C@@H](O)CNC1CCN(CC1)c1ccc(Cc2sc(=O)[nH]c2O)cc1
InChI Key: InChIKey=UCWNAIHSSOGALM-NRFANRHFSA-N
Data: 4 EC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Beta-2 adrenergic receptor (Homo sapiens (Human)) | BDBM50097798![]() (CHEMBL163262 | N-[5-((R)-2-{1-[4-(2,4-Dioxo-thiazo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 1.19E+3 | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research Curated by ChEMBL | Assay Description Agonistic activity was assessed by measurement of cAMP accumulation levels in CHO cells expressing human beta-2-adrenergic receptor | Bioorg Med Chem Lett 11: 757-60 (2001) BindingDB Entry DOI: 10.7270/Q2BP022B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-3 adrenergic receptor (Homo sapiens (Human)) | BDBM50097798![]() (CHEMBL163262 | N-[5-((R)-2-{1-[4-(2,4-Dioxo-thiazo...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research Curated by ChEMBL | Assay Description Beta 3-adrenergic receptor agonistic activity as cAMP accumulation in CHO cells | Bioorg Med Chem Lett 11: 981-4 (2001) BindingDB Entry DOI: 10.7270/Q2125RZ5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-1 adrenergic receptor (Homo sapiens (Human)) | BDBM50097798![]() (CHEMBL163262 | N-[5-((R)-2-{1-[4-(2,4-Dioxo-thiazo...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 2.72E+3 | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research Curated by ChEMBL | Assay Description Agonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptor | Bioorg Med Chem Lett 11: 757-60 (2001) BindingDB Entry DOI: 10.7270/Q2BP022B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-3 adrenergic receptor (Homo sapiens (Human)) | BDBM50097798![]() (CHEMBL163262 | N-[5-((R)-2-{1-[4-(2,4-Dioxo-thiazo...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research Curated by ChEMBL | Assay Description Agonistic activity as cAMP accumulation in CHO cells expressing human beta-3-andrenergic receptor | Bioorg Med Chem Lett 11: 757-60 (2001) BindingDB Entry DOI: 10.7270/Q2BP022B | |||||||||||
More data for this Ligand-Target Pair |