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BDBM50099167 CHEMBL369155::N'-[5-(4-{4-[(S)-2-Hydroxy-3-(4-hydroxy-phenoxy)-propylamino]-piperidin-1-yl}-benzylidene)-4-oxo-4,5-dihydro-thiazol-2-yl]-N,N-dimethyl-guanidine

SMILES: CN(C)C(=N)NC1=NC(=O)C(S1)=Cc1ccc(cc1)N1CCC(CC1)NC[C@H](O)COc1ccc(O)cc1

InChI Key: InChIKey=WYEDYMVEMZLAMY-QFIPXVFZSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50099167   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Beta-3 adrenergic receptor


(Homo sapiens (Human))		BDBM50099167
PNG
(CHEMBL369155 | N'-[5-(4-{4-[(S)-2-Hydroxy-3-(4-hyd...)
Show SMILES CN(C)C(=N)NC1=NC(=O)C(S1)=Cc1ccc(cc1)N1CCC(CC1)NC[C@H](O)COc1ccc(O)cc1 |w:12.13,t:6|
Show InChI InChI=1S/C27H34N6O4S/c1-32(2)26(28)31-27-30-25(36)24(38-27)15-18-3-5-20(6-4-18)33-13-11-19(12-14-33)29-16-22(35)17-37-23-9-7-21(34)8-10-23/h3-10,15,19,22,29,34-35H,11-14,16-17H2,1-2H3,(H2,28,30,31,36)/t22-/m0/s1
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PubMed
n/an/an/an/a 400n/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Beta 3-adrenergic receptor agonistic activity, evaluated by measurement of cAMP accumulation in CHO cells.

Bioorg Med Chem Lett 11: 981-4 (2001)


BindingDB Entry DOI: 10.7270/Q2125RZ5
More data for this
Ligand-Target Pair