BDBM50099232 1-[3-(4-Isopropyl-naphthalen-1-yl)-8-methyl-8-aza-bicyclo[3.2.1]oct-2-yl]-propan-1-one::CHEMBL290662
SMILES: CCC(=O)C1C2CCC(CC1c1ccc(C(C)C)c3ccccc13)N2C
InChI Key: InChIKey=RBRMVWHMOIEQRO-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Sodium-dependent serotonin transporter (Rattus norvegicus (rat)) | BDBM50099232 (1-[3-(4-Isopropyl-naphthalen-1-yl)-8-methyl-8-aza-...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 136 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
State University of New York Curated by ChEMBL | Assay Description Affinity for the displacement of [3H]-paroxetine binding to serotonin transporter (SERT) in rat frontal cortex membranes | J Med Chem 44: 1509-15 (2001) BindingDB Entry DOI: 10.7270/Q2H1318R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transporter (Rattus norvegicus) | BDBM50099232 (1-[3-(4-Isopropyl-naphthalen-1-yl)-8-methyl-8-aza-...) | Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
State University of New York Curated by ChEMBL | Assay Description Affinity for the displacement of [3H]-paroxetine binding to norepinephrine transporter (NET) in rat frontal cortex membranes | J Med Chem 44: 1509-15 (2001) BindingDB Entry DOI: 10.7270/Q2H1318R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM50099232 (1-[3-(4-Isopropyl-naphthalen-1-yl)-8-methyl-8-aza-...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 225 | n/a | n/a | n/a | n/a | n/a | n/a |
State University of New York Curated by ChEMBL | Assay Description Inhibitory activity in displacing [125I]- RTI-55 binding to dopamine transporter in rat striatal membranes | J Med Chem 44: 1509-15 (2001) BindingDB Entry DOI: 10.7270/Q2H1318R | |||||||||||
More data for this Ligand-Target Pair |