BDBM50099662 CHEMBL3319481
SMILES: COc1ccc(C[C@H](NC(=O)[C@H](C)NC(=O)CN2CCOCC2)C(=O)N[C@@H](CC2CCCCC2)C(=O)[C@@]2(C)CO2)cc1
InChI Key: InChIKey=YXEYBIQZOWYSHS-UHFFFAOYSA-N
Data: 6 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
26S proteosome (Homo sapiens (Human)) | BDBM50099662 (CHEMBL3319481) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden Institute of Chemistry and Netherlands Proteomics Centre Curated by ChEMBL | Assay Description Inhibition of proteasome subunit beta-5i in human Raji cells using BODIPY-NC005 by fluorescent densitometry | J Med Chem 57: 6197-209 (2014) Article DOI: 10.1021/jm500716s BindingDB Entry DOI: 10.7270/Q2BR8TZT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proteasome subunit beta type-9 (Homo sapiens (Human)) | BDBM50099662 (CHEMBL3319481) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden Institute of Chemistry and Netherlands Proteomics Centre Curated by ChEMBL | Assay Description Inhibition of proteasome subunit beta-1i in human Raji cells using BODIPY- epoxomicin by fluorescent densitometry | J Med Chem 57: 6197-209 (2014) Article DOI: 10.1021/jm500716s BindingDB Entry DOI: 10.7270/Q2BR8TZT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proteasome subunit beta type-10 (Homo sapiens (Human)) | BDBM50099662 (CHEMBL3319481) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden Institute of Chemistry and Netherlands Proteomics Centre Curated by ChEMBL | Assay Description Inhibition of proteasome subunit beta-2i in human RPMI8226 cells using BODIPY-epoxomicin by fluorescent densitometry | J Med Chem 57: 6197-209 (2014) Article DOI: 10.1021/jm500716s BindingDB Entry DOI: 10.7270/Q2BR8TZT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
26S proteosome (Homo sapiens (Human)) | BDBM50099662 (CHEMBL3319481) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden Institute of Chemistry and Netherlands Proteomics Centre Curated by ChEMBL | Assay Description Inhibition of proteasome subunit beta-5i in human RPMI8226 cells using BODIPY-NC005 by fluorescent densitometry | J Med Chem 57: 6197-209 (2014) Article DOI: 10.1021/jm500716s BindingDB Entry DOI: 10.7270/Q2BR8TZT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proteasome subunit beta type-9 (Homo sapiens (Human)) | BDBM50099662 (CHEMBL3319481) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 370 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden Institute of Chemistry and Netherlands Proteomics Centre Curated by ChEMBL | Assay Description Inhibition of proteasome subunit beta-1i in human RPMI8226 cells using BODIPY-NC001 by fluorescent densitometry | J Med Chem 57: 6197-209 (2014) Article DOI: 10.1021/jm500716s BindingDB Entry DOI: 10.7270/Q2BR8TZT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proteasome subunit beta type-10 (Homo sapiens (Human)) | BDBM50099662 (CHEMBL3319481) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 410 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden Institute of Chemistry and Netherlands Proteomics Centre Curated by ChEMBL | Assay Description Inhibition of proteasome subunit beta-2i in human Raji cells using BODIPY- epoxomicin by fluorescent densitometry | J Med Chem 57: 6197-209 (2014) Article DOI: 10.1021/jm500716s BindingDB Entry DOI: 10.7270/Q2BR8TZT | |||||||||||
More data for this Ligand-Target Pair |