BDBM50103185 CHEMBL3393194
SMILES: COc1cc2nncc(-c3cnc(N4CCC(O)(CC4)c4cccnc4)c(C)c3)c2cc1OC
InChI Key: InChIKey=FEGRSUIQAKRFCI-UHFFFAOYSA-N
Data: 5 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Homo sapiens (Human)) | BDBM50103185 (CHEMBL3393194) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 7.83E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Washington University School of Medicine Curated by ChEMBL | Assay Description Inhibition of human recombinant PDE4A pre-incubated for 5 mins before [3H]cAMP substrate addition and measured 20 mins post substrate addition by sci... | Bioorg Med Chem Lett 25: 919-24 (2015) BindingDB Entry DOI: 10.7270/Q2H41T6N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cGMP-inhibited 3',5'-cyclic phosphodiesterase B (Homo sapiens (Human)) | BDBM50103185 (CHEMBL3393194) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 4.11E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Washington University School of Medicine Curated by ChEMBL | Assay Description Inhibition of human recombinant PDE3B pre-incubated for 5 mins before [3H]cAMP substrate addition and measured 20 mins post substrate addition by sci... | Bioorg Med Chem Lett 25: 919-24 (2015) BindingDB Entry DOI: 10.7270/Q2H41T6N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM50103185 (CHEMBL3393194) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 8.73E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Washington University School of Medicine Curated by ChEMBL | Assay Description Inhibition of human recombinant PDE4B pre-incubated for 5 mins before [3H]cAMP substrate addition and measured 20 mins post substrate addition by sci... | Bioorg Med Chem Lett 25: 919-24 (2015) BindingDB Entry DOI: 10.7270/Q2H41T6N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM50103185 (CHEMBL3393194) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Washington University School of Medicine Curated by ChEMBL | Assay Description Inhibition of human recombinant PDE10A catalytic domain pre-incubated for 5 mins before [3H]cAMP substrate addition and measured 20 mins post substra... | Bioorg Med Chem Lett 25: 919-24 (2015) BindingDB Entry DOI: 10.7270/Q2H41T6N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase 3 (PDE3) (Homo sapiens (Human)) | BDBM50103185 (CHEMBL3393194) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 3.07E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Washington University School of Medicine Curated by ChEMBL | Assay Description Inhibition of human recombinant PDE3A pre-incubated for 5 mins before [3H]cAMP substrate addition and measured 20 mins post substrate addition by sci... | Bioorg Med Chem Lett 25: 919-24 (2015) BindingDB Entry DOI: 10.7270/Q2H41T6N | |||||||||||
More data for this Ligand-Target Pair |