BDBM50103327 4-(5-{[(1-Benzyl-2-oxo-pyrrolidin-3-yl)-phenethyl-amino]-methyl}-imidazol-1-ylmethyl)-benzonitrile::CHEMBL318943

SMILES: O=C1[C@H](CCN1Cc1ccccc1)N(CCc1ccccc1)Cc1cncn1Cc1ccc(cc1)C#N

InChI Key: InChIKey=NGWHQWBIMKMHDC-PMERELPUSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50103327   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Geranylgeranyl transferase type I (Homo sapiens (Human))	BDBM50103327 (4-(5-{[(1-Benzyl-2-oxo-pyrrolidin-3-yl)-phenethyl-...) Show SMILES O=C1[C@H](CCN1Cc1ccccc1)N(CCc1ccccc1)Cc1cncn1Cc1ccc(cc1)C#N Show InChI InChI=1S/C31H31N5O/c32-19-26-11-13-28(14-12-26)22-36-24-33-20-29(36)23-34(17-15-25-7-3-1-4-8-25)30-16-18-35(31(30)37)21-27-9-5-2-6-10-27/h1-14,20,24,30H,15-18,21-23H2/t30-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration of geranylgeranyl-protein transferase type I				J Med Chem 44: 2933-49 (2001) BindingDB Entry DOI: 10.7270/Q2FF3RNW
					More data for this Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B (Homo sapiens (Human))	BDBM50103327 (4-(5-{[(1-Benzyl-2-oxo-pyrrolidin-3-yl)-phenethyl-...) Show SMILES O=C1[C@H](CCN1Cc1ccccc1)N(CCc1ccccc1)Cc1cncn1Cc1ccc(cc1)C#N Show InChI InChI=1S/C31H31N5O/c32-19-26-11-13-28(14-12-26)22-36-24-33-20-29(36)23-34(17-15-25-7-3-1-4-8-25)30-16-18-35(31(30)37)21-27-9-5-2-6-10-27/h1-14,20,24,30H,15-18,21-23H2/t30-/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	460	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Concentration required to displace 50% of a potent radiolabeled FTI from farnesyl transferase in cultured H-ras-transformed Rat1 cells				J Med Chem 44: 2933-49 (2001) BindingDB Entry DOI: 10.7270/Q2FF3RNW
					More data for this Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B (Homo sapiens (Human))	BDBM50103327 (4-(5-{[(1-Benzyl-2-oxo-pyrrolidin-3-yl)-phenethyl-...) Show SMILES O=C1[C@H](CCN1Cc1ccccc1)N(CCc1ccccc1)Cc1cncn1Cc1ccc(cc1)C#N Show InChI InChI=1S/C31H31N5O/c32-19-26-11-13-28(14-12-26)22-36-24-33-20-29(36)23-34(17-15-25-7-3-1-4-8-25)30-16-18-35(31(30)37)21-27-9-5-2-6-10-27/h1-14,20,24,30H,15-18,21-23H2/t30-/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	51	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description In vitro inhibition of farnesyl transferase using purified recombinant human enzyme				J Med Chem 44: 2933-49 (2001) BindingDB Entry DOI: 10.7270/Q2FF3RNW
					More data for this Ligand-Target Pair