BDBM50103349 4-(5-{[1-(2-Chloro-benzoyl)-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile::CHEMBL101564

SMILES: Clc1ccccc1C(=O)N1CC[C@@H](C1)NCc1cncn1Cc1ccc(cc1)C#N

InChI Key: InChIKey=IHJXPUJVCXRXDC-IBGZPJMESA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50103349   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Farnesyltransferase (PFT) Chain B (Homo sapiens (Human))	BDBM50103349 (4-(5-{[1-(2-Chloro-benzoyl)-pyrrolidin-3-ylamino]-...) Show SMILES Clc1ccccc1C(=O)N1CC[C@@H](C1)NCc1cncn1Cc1ccc(cc1)C#N Show InChI InChI=1S/C23H22ClN5O/c24-22-4-2-1-3-21(22)23(30)28-10-9-19(15-28)27-13-20-12-26-16-29(20)14-18-7-5-17(11-25)6-8-18/h1-8,12,16,19,27H,9-10,13-15H2/t19-/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description In vitro inhibition of farnesyl transferase using purified recombinant human enzyme				J Med Chem 44: 2933-49 (2001) BindingDB Entry DOI: 10.7270/Q2FF3RNW
					More data for this Ligand-Target Pair
Geranylgeranyl transferase type I (Homo sapiens (Human))	BDBM50103349 (4-(5-{[1-(2-Chloro-benzoyl)-pyrrolidin-3-ylamino]-...) Show SMILES Clc1ccccc1C(=O)N1CC[C@@H](C1)NCc1cncn1Cc1ccc(cc1)C#N Show InChI InChI=1S/C23H22ClN5O/c24-22-4-2-1-3-21(22)23(30)28-10-9-19(15-28)27-13-20-12-26-16-29(20)14-18-7-5-17(11-25)6-8-18/h1-8,12,16,19,27H,9-10,13-15H2/t19-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration of geranylgeranyl-protein transferase type I				J Med Chem 44: 2933-49 (2001) BindingDB Entry DOI: 10.7270/Q2FF3RNW
					More data for this Ligand-Target Pair