BDBM50103818 (6-Benzhydryl-piperidin-3-yl)-(4-fluoro-benzyl)-amine::CHEMBL40607

SMILES: Fc1ccc(CNC2CCC(NC2)C(c2ccccc2)c2ccccc2)cc1

InChI Key: InChIKey=KQGGYEZSINLKFH-UHFFFAOYSA-N

Data: 12 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50103818   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Norepinephrine Monoamine transporters (Rattus norvegicus)	BDBM50103818 ((6-Benzhydryl-piperidin-3-yl)-(4-fluoro-benzyl)-am...) Show SMILES Fc1ccc(CNC2CCC(NC2)C(c2ccccc2)c2ccccc2)cc1 Show InChI InChI=1S/C25H27FN2/c26-22-13-11-19(12-14-22)17-27-23-15-16-24(28-18-23)25(20-7-3-1-4-8-20)21-9-5-2-6-10-21/h1-14,23-25,27-28H,15-18H2	Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.35E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wayne State University Curated by ChEMBL					Assay Description Binding affinity was evaluated by measuring inhibiting the binding of [3H]nisoxetine to Norepinephrine transporter in rat brain tissue				Bioorg Med Chem Lett 11: 2337-40 (2001) BindingDB Entry DOI: 10.7270/Q2WH2QH1
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rattus norvegicus (rat))	BDBM50103818 ((6-Benzhydryl-piperidin-3-yl)-(4-fluoro-benzyl)-am...) Show SMILES Fc1ccc(CNC2CCC(NC2)C(c2ccccc2)c2ccccc2)cc1 Show InChI InChI=1S/C25H27FN2/c26-22-13-11-19(12-14-22)17-27-23-15-16-24(28-18-23)25(20-7-3-1-4-8-20)21-9-5-2-6-10-21/h1-14,23-25,27-28H,15-18H2	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.33E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wayne State University Curated by ChEMBL					Assay Description Binding affinity was evaluated by measuring inhibiting the binding of [3H]citalopram to Serotonin transporter in rat brain tissue				Bioorg Med Chem Lett 11: 2337-40 (2001) BindingDB Entry DOI: 10.7270/Q2WH2QH1
					More data for this Ligand-Target Pair
Monoamine transporters; Norepininephrine & dopamine (Rattus norvegicus)	BDBM50103818 ((6-Benzhydryl-piperidin-3-yl)-(4-fluoro-benzyl)-am...) Show SMILES Fc1ccc(CNC2CCC(NC2)C(c2ccccc2)c2ccccc2)cc1 Show InChI InChI=1S/C25H27FN2/c26-22-13-11-19(12-14-22)17-27-23-15-16-24(28-18-23)25(20-7-3-1-4-8-20)21-9-5-2-6-10-21/h1-14,23-25,27-28H,15-18H2	Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	4.47E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wayne State University Curated by ChEMBL					Assay Description Binding affinity was evaluated by measuring inhibiting the binding of [3H]nisoxetine to Norepinephrine transporter in rat brain tissue				Bioorg Med Chem Lett 11: 2337-40 (2001) BindingDB Entry DOI: 10.7270/Q2WH2QH1
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rattus norvegicus (rat))	BDBM50103818 ((6-Benzhydryl-piperidin-3-yl)-(4-fluoro-benzyl)-am...) Show SMILES Fc1ccc(CNC2CCC(NC2)C(c2ccccc2)c2ccccc2)cc1 Show InChI InChI=1S/C25H27FN2/c26-22-13-11-19(12-14-22)17-27-23-15-16-24(28-18-23)25(20-7-3-1-4-8-20)21-9-5-2-6-10-21/h1-14,23-25,27-28H,15-18H2	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.81E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wayne State University Curated by ChEMBL					Assay Description Binding affinity was evaluated by measuring inhibiting the binding of [3H]citalopram to Serotonin transporter in rat brain tissue				Bioorg Med Chem Lett 11: 2337-40 (2001) BindingDB Entry DOI: 10.7270/Q2WH2QH1
					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Rattus norvegicus (rat))	BDBM50103818 ((6-Benzhydryl-piperidin-3-yl)-(4-fluoro-benzyl)-am...) Show SMILES Fc1ccc(CNC2CCC(NC2)C(c2ccccc2)c2ccccc2)cc1 Show InChI InChI=1S/C25H27FN2/c26-22-13-11-19(12-14-22)17-27-23-15-16-24(28-18-23)25(20-7-3-1-4-8-20)21-9-5-2-6-10-21/h1-14,23-25,27-28H,15-18H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Wayne State University Curated by ChEMBL					Assay Description Binding affinity was evaluated by measuring the inhibition of [3H]WIN-35428 binding to Dopamine transporter in rat brain tissue				Bioorg Med Chem Lett 11: 2337-40 (2001) BindingDB Entry DOI: 10.7270/Q2WH2QH1
					More data for this Ligand-Target Pair
Norepinephrine Monoamine transporters (Rattus norvegicus)	BDBM50103818 ((6-Benzhydryl-piperidin-3-yl)-(4-fluoro-benzyl)-am...) Show SMILES Fc1ccc(CNC2CCC(NC2)C(c2ccccc2)c2ccccc2)cc1 Show InChI InChI=1S/C25H27FN2/c26-22-13-11-19(12-14-22)17-27-23-15-16-24(28-18-23)25(20-7-3-1-4-8-20)21-9-5-2-6-10-21/h1-14,23-25,27-28H,15-18H2	Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.42E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wayne State University Curated by ChEMBL					Assay Description Inhibition of [3H]nisoxetine binding to norepinephrine transporter of rat cerebral cortex				J Med Chem 47: 5101-13 (2004) Article DOI: 10.1021/jm049796t BindingDB Entry DOI: 10.7270/Q2HQ40P0
					More data for this Ligand-Target Pair
Norepinephrine Monoamine transporters (Rattus norvegicus)	BDBM50103818 ((6-Benzhydryl-piperidin-3-yl)-(4-fluoro-benzyl)-am...) Show SMILES Fc1ccc(CNC2CCC(NC2)C(c2ccccc2)c2ccccc2)cc1 Show InChI InChI=1S/C25H27FN2/c26-22-13-11-19(12-14-22)17-27-23-15-16-24(28-18-23)25(20-7-3-1-4-8-20)21-9-5-2-6-10-21/h1-14,23-25,27-28H,15-18H2	Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.02E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wayne State University Curated by ChEMBL					Assay Description Inhibition of binding of [3H]nisoxetine to (NET) norepinephrine transporter in rat striatum				Bioorg Med Chem Lett 13: 1591-5 (2003) BindingDB Entry DOI: 10.7270/Q2J38T3X
					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Rattus norvegicus (rat))	BDBM50103818 ((6-Benzhydryl-piperidin-3-yl)-(4-fluoro-benzyl)-am...) Show SMILES Fc1ccc(CNC2CCC(NC2)C(c2ccccc2)c2ccccc2)cc1 Show InChI InChI=1S/C25H27FN2/c26-22-13-11-19(12-14-22)17-27-23-15-16-24(28-18-23)25(20-7-3-1-4-8-20)21-9-5-2-6-10-21/h1-14,23-25,27-28H,15-18H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
Wayne State University Curated by ChEMBL					Assay Description Inhibition of binding of [3H]WIN-35 428 to (DAT) dopamine transporter in rat striatum				Bioorg Med Chem Lett 13: 1591-5 (2003) BindingDB Entry DOI: 10.7270/Q2J38T3X
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rattus norvegicus (rat))	BDBM50103818 ((6-Benzhydryl-piperidin-3-yl)-(4-fluoro-benzyl)-am...) Show SMILES Fc1ccc(CNC2CCC(NC2)C(c2ccccc2)c2ccccc2)cc1 Show InChI InChI=1S/C25H27FN2/c26-22-13-11-19(12-14-22)17-27-23-15-16-24(28-18-23)25(20-7-3-1-4-8-20)21-9-5-2-6-10-21/h1-14,23-25,27-28H,15-18H2	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.22E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wayne State University Curated by ChEMBL					Assay Description Inhibition of binding of [3H]citalopram to (SERT) serotonin transporter in rat striatum				Bioorg Med Chem Lett 13: 1591-5 (2003) BindingDB Entry DOI: 10.7270/Q2J38T3X
					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Rattus norvegicus (rat))	BDBM50103818 ((6-Benzhydryl-piperidin-3-yl)-(4-fluoro-benzyl)-am...) Show SMILES Fc1ccc(CNC2CCC(NC2)C(c2ccccc2)c2ccccc2)cc1 Show InChI InChI=1S/C25H27FN2/c26-22-13-11-19(12-14-22)17-27-23-15-16-24(28-18-23)25(20-7-3-1-4-8-20)21-9-5-2-6-10-21/h1-14,23-25,27-28H,15-18H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	33.8	n/a	n/a	n/a	n/a	n/a	n/a
Wayne State University Curated by ChEMBL					Assay Description Inhibition of [3H]WIN-35428 binding to dopamine transporter of rat striatum				J Med Chem 47: 5101-13 (2004) Article DOI: 10.1021/jm049796t BindingDB Entry DOI: 10.7270/Q2HQ40P0
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rattus norvegicus (rat))	BDBM50103818 ((6-Benzhydryl-piperidin-3-yl)-(4-fluoro-benzyl)-am...) Show SMILES Fc1ccc(CNC2CCC(NC2)C(c2ccccc2)c2ccccc2)cc1 Show InChI InChI=1S/C25H27FN2/c26-22-13-11-19(12-14-22)17-27-23-15-16-24(28-18-23)25(20-7-3-1-4-8-20)21-9-5-2-6-10-21/h1-14,23-25,27-28H,15-18H2	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.33E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wayne State University Curated by ChEMBL					Assay Description Inhibition of [3H]citalopram binding to serotonin transporter of rat cerebral cortex				J Med Chem 47: 5101-13 (2004) Article DOI: 10.1021/jm049796t BindingDB Entry DOI: 10.7270/Q2HQ40P0
					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Rattus norvegicus (rat))	BDBM50103818 ((6-Benzhydryl-piperidin-3-yl)-(4-fluoro-benzyl)-am...) Show SMILES Fc1ccc(CNC2CCC(NC2)C(c2ccccc2)c2ccccc2)cc1 Show InChI InChI=1S/C25H27FN2/c26-22-13-11-19(12-14-22)17-27-23-15-16-24(28-18-23)25(20-7-3-1-4-8-20)21-9-5-2-6-10-21/h1-14,23-25,27-28H,15-18H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Wayne State University Curated by ChEMBL					Assay Description Binding affinity was evaluated by measuring the inhibition of [3H]WIN-35428 binding to Dopamine transporter in rat brain tissue				Bioorg Med Chem Lett 11: 2337-40 (2001) BindingDB Entry DOI: 10.7270/Q2WH2QH1
					More data for this Ligand-Target Pair