BDBM50104968 CHEMBL114804::N*4*-Hydroxy-N*1*-(2-hydroxy-indan-1-yl)-2-(4-methoxy-benzyl)-succinamide
SMILES: COc1ccc(C[C@H](CC(=O)NO)C(=O)N[C@@H]2[C@H](O)Cc3ccccc23)cc1
InChI Key: InChIKey=VUKNURXXGDIFMO-ZTNFWEORSA-N
Data: 4 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Neutrophil collagenase (Homo sapiens (Human)) | BDBM50104968 (CHEMBL114804 | N*4*-Hydroxy-N*1*-(2-hydroxy-indan-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 9.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The DuPont Pharmaceuticals Company Curated by ChEMBL | Assay Description Inhibition of matrix metalloprotease-8 | J Med Chem 44: 3347-50 (2001) BindingDB Entry DOI: 10.7270/Q2057F7H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
72 kDa type IV collagenase (Homo sapiens (Human)) | BDBM50104968 (CHEMBL114804 | N*4*-Hydroxy-N*1*-(2-hydroxy-indan-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 52 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The DuPont Pharmaceuticals Company Curated by ChEMBL | Assay Description Inhibition of matrix metalloprotease-2 | J Med Chem 44: 3347-50 (2001) BindingDB Entry DOI: 10.7270/Q2057F7H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Matrix metalloproteinase-9 (Homo sapiens (Human)) | BDBM50104968 (CHEMBL114804 | N*4*-Hydroxy-N*1*-(2-hydroxy-indan-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 203 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The DuPont Pharmaceuticals Company Curated by ChEMBL | Assay Description Inhibition of human matrix metalloprotease-9 | J Med Chem 44: 3347-50 (2001) BindingDB Entry DOI: 10.7270/Q2057F7H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interstitial collagenase (Homo sapiens (Human)) | BDBM50104968 (CHEMBL114804 | N*4*-Hydroxy-N*1*-(2-hydroxy-indan-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.16E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The DuPont Pharmaceuticals Company Curated by ChEMBL | Assay Description Inhibition of matrix metalloprotease-1 | J Med Chem 44: 3347-50 (2001) BindingDB Entry DOI: 10.7270/Q2057F7H | |||||||||||
More data for this Ligand-Target Pair |