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SMILES: Cc1[nH]n(-c2cccc(c2)[N+]([O-])=O)c(=O)c1N=Nc1c(O)cc(c2ccccc12)S(O)(=O)=O

InChI Key: InChIKey=JLTRRIPKQVAQBW-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50105972   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Thrombopoietin receptor


(Homo sapiens (Human))		BDBM50105972
PNG
(3-Hydroxy-4-{N'-[3-methyl-1-(3-nitro-phenyl)-5-oxo...)
Show SMILES Cc1[nH]n(-c2cccc(c2)[N+]([O-])=O)c(=O)c1N=Nc1c(O)cc(c2ccccc12)S(O)(=O)=O |w:17.19|
Show InChI InChI=1S/C20H15N5O7S/c1-11-18(20(27)24(23-11)12-5-4-6-13(9-12)25(28)29)21-22-19-15-8-3-2-7-14(15)17(10-16(19)26)33(30,31)32/h2-10,23,26H,1H3,(H,30,31,32)
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PubMed
n/an/an/an/a 300n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Effective concentration for thrombopoietin luciferase activity was determined in BAF-3 cells

J Med Chem 44: 3730-45 (2001)


BindingDB Entry DOI: 10.7270/Q2MP52KF
More data for this
Ligand-Target Pair