BDBM50107280 CHEMBL3600788

SMILES: Cl.OC(=O)c1ccc(cc1)C1(CC1)NC(=O)[C@H]1CCCCN1CCOc1ccccc1

InChI Key: InChIKey=YBLUWXOCESHXEV-OAQYLSRUSA-N

Data: 1 KI  3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50107280   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50107280 (CHEMBL3600788) Show SMILES Cl.OC(=O)c1ccc(cc1)C1(CC1)NC(=O)[C@H]1CCCCN1CCOc1ccccc1 |r| Show InChI InChI=1S/C24H28N2O4/c27-22(25-24(13-14-24)19-11-9-18(10-12-19)23(28)29)21-8-4-5-15-26(21)16-17-30-20-6-2-1-3-7-20/h1-3,6-7,9-12,21H,4-5,8,13-17H2,(H,25,27)(H,28,29)/t21-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	45	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [3H]-PGE2 from recombinant human EP4 receptor expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting analy...				Bioorg Med Chem Lett 25: 3176-8 (2015) BindingDB Entry DOI: 10.7270/Q2FX7C79
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50107280 (CHEMBL3600788) Show SMILES Cl.OC(=O)c1ccc(cc1)C1(CC1)NC(=O)[C@H]1CCCCN1CCOc1ccccc1 |r| Show InChI InChI=1S/C24H28N2O4/c27-22(25-24(13-14-24)19-11-9-18(10-12-19)23(28)29)21-8-4-5-15-26(21)16-17-30-20-6-2-1-3-7-20/h1-3,6-7,9-12,21H,4-5,8,13-17H2,(H,25,27)(H,28,29)/t21-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	78	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Displacement of [3H]-PGE2 from recombinant human EP4 receptor expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting analy...				Bioorg Med Chem Lett 25: 3176-8 (2015) BindingDB Entry DOI: 10.7270/Q2FX7C79
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50107280 (CHEMBL3600788) Show SMILES Cl.OC(=O)c1ccc(cc1)C1(CC1)NC(=O)[C@H]1CCCCN1CCOc1ccccc1 |r| Show InChI InChI=1S/C24H28N2O4/c27-22(25-24(13-14-24)19-11-9-18(10-12-19)23(28)29)21-8-4-5-15-26(21)16-17-30-20-6-2-1-3-7-20/h1-3,6-7,9-12,21H,4-5,8,13-17H2,(H,25,27)(H,28,29)/t21-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	586	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Antagonist activity at EP4 receptor in LPS-stimulated human whole blood assessed as inhibition of PGE2-induced TNF-alpha reduction preincubated for 3...				Bioorg Med Chem Lett 25: 3176-8 (2015) BindingDB Entry DOI: 10.7270/Q2FX7C79
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50107280 (CHEMBL3600788) Show SMILES Cl.OC(=O)c1ccc(cc1)C1(CC1)NC(=O)[C@H]1CCCCN1CCOc1ccccc1 |r| Show InChI InChI=1S/C24H28N2O4/c27-22(25-24(13-14-24)19-11-9-18(10-12-19)23(28)29)21-8-4-5-15-26(21)16-17-30-20-6-2-1-3-7-20/h1-3,6-7,9-12,21H,4-5,8,13-17H2,(H,25,27)(H,28,29)/t21-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	5.40	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Antagonist activity at recombinant human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP accumulation by scinti...				Bioorg Med Chem Lett 25: 3176-8 (2015) BindingDB Entry DOI: 10.7270/Q2FX7C79
					More data for this Ligand-Target Pair