BDBM50108149 CHEMBL75189::N-Hydroxy-N-{3-morpholin-4-yl-1-[4-(4-trifluoromethoxy-phenoxy)-benzenesulfonylmethyl]-propyl}-formamide

SMILES: ON(C=O)C(CCN1CCOCC1)CS(=O)(=O)c1ccc(Oc2ccc(OC(F)(F)F)cc2)cc1

InChI Key: InChIKey=ZOYPENCXBQHGNW-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50108149   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50108149 (CHEMBL75189 | N-Hydroxy-N-{3-morpholin-4-yl-1-[4-(...) Show SMILES ON(C=O)C(CCN1CCOCC1)CS(=O)(=O)c1ccc(Oc2ccc(OC(F)(F)F)cc2)cc1 Show InChI InChI=1S/C22H25F3N2O7S/c23-22(24,25)34-20-3-1-18(2-4-20)33-19-5-7-21(8-6-19)35(30,31)15-17(27(29)16-28)9-10-26-11-13-32-14-12-26/h1-8,16-17,29H,9-15H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro selective inhibition against Matrix metalloprotease-9 (MMP-9) using fluorimetric assay				J Med Chem 45: 219-32 (2001) BindingDB Entry DOI: 10.7270/Q2XP747B
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50108149 (CHEMBL75189 | N-Hydroxy-N-{3-morpholin-4-yl-1-[4-(...) Show SMILES ON(C=O)C(CCN1CCOCC1)CS(=O)(=O)c1ccc(Oc2ccc(OC(F)(F)F)cc2)cc1 Show InChI InChI=1S/C22H25F3N2O7S/c23-22(24,25)34-20-3-1-18(2-4-20)33-19-5-7-21(8-6-19)35(30,31)15-17(27(29)16-28)9-10-26-11-13-32-14-12-26/h1-8,16-17,29H,9-15H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of MMP9				ACS Med Chem Lett 2: 455-460 (2011) Article DOI: 10.1021/ml200031m BindingDB Entry DOI: 10.7270/Q2HQ40ZK
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50108149 (CHEMBL75189 | N-Hydroxy-N-{3-morpholin-4-yl-1-[4-(...) Show SMILES ON(C=O)C(CCN1CCOCC1)CS(=O)(=O)c1ccc(Oc2ccc(OC(F)(F)F)cc2)cc1 Show InChI InChI=1S/C22H25F3N2O7S/c23-22(24,25)34-20-3-1-18(2-4-20)33-19-5-7-21(8-6-19)35(30,31)15-17(27(29)16-28)9-10-26-11-13-32-14-12-26/h1-8,16-17,29H,9-15H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	0.570	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro selective inhibition against matrix metalloprotease-2 (MMP-2) using fluorimetric assay				J Med Chem 45: 219-32 (2001) BindingDB Entry DOI: 10.7270/Q2XP747B
					More data for this Ligand-Target Pair
Interstitial collagenase (Homo sapiens (Human))	BDBM50108149 (CHEMBL75189 | N-Hydroxy-N-{3-morpholin-4-yl-1-[4-(...) Show SMILES ON(C=O)C(CCN1CCOCC1)CS(=O)(=O)c1ccc(Oc2ccc(OC(F)(F)F)cc2)cc1 Show InChI InChI=1S/C22H25F3N2O7S/c23-22(24,25)34-20-3-1-18(2-4-20)33-19-5-7-21(8-6-19)35(30,31)15-17(27(29)16-28)9-10-26-11-13-32-14-12-26/h1-8,16-17,29H,9-15H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro selective inhibition against matrix metalloprotease-1 (MMP-1) using a fluorimetric assay				J Med Chem 45: 219-32 (2001) BindingDB Entry DOI: 10.7270/Q2XP747B
					More data for this Ligand-Target Pair