BDBM50108157 CHEMBL75139::N-[2-[4-(4-Chloro-phenoxy)-benzenesulfonyl]-1-(3,4,4-trimethyl-2,5-dioxo-imidazolidin-1-ylmethyl)-ethyl]-N-hydroxy-formamide

SMILES: CN1C(=O)N(CC(CS(=O)(=O)c2ccc(Oc3ccc(Cl)cc3)cc2)N(O)C=O)C(=O)C1(C)C

InChI Key: InChIKey=SBVGWUXDJBPGDG-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50108157   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50108157 (CHEMBL75139 | N-[2-[4-(4-Chloro-phenoxy)-benzenesu...) Show SMILES CN1C(=O)N(CC(CS(=O)(=O)c2ccc(Oc3ccc(Cl)cc3)cc2)N(O)C=O)C(=O)C1(C)C Show InChI InChI=1S/C22H24ClN3O7S/c1-22(2)20(28)25(21(29)24(22)3)12-16(26(30)14-27)13-34(31,32)19-10-8-18(9-11-19)33-17-6-4-15(23)5-7-17/h4-11,14,16,30H,12-13H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro selective inhibition against Matrix metalloprotease-9 (MMP-9) using fluorimetric assay				J Med Chem 45: 219-32 (2001) BindingDB Entry DOI: 10.7270/Q2XP747B
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50108157 (CHEMBL75139 | N-[2-[4-(4-Chloro-phenoxy)-benzenesu...) Show SMILES CN1C(=O)N(CC(CS(=O)(=O)c2ccc(Oc3ccc(Cl)cc3)cc2)N(O)C=O)C(=O)C1(C)C Show InChI InChI=1S/C22H24ClN3O7S/c1-22(2)20(28)25(21(29)24(22)3)12-16(26(30)14-27)13-34(31,32)19-10-8-18(9-11-19)33-17-6-4-15(23)5-7-17/h4-11,14,16,30H,12-13H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of MMP9				ACS Med Chem Lett 2: 455-460 (2011) Article DOI: 10.1021/ml200031m BindingDB Entry DOI: 10.7270/Q2HQ40ZK
					More data for this Ligand-Target Pair
Interstitial collagenase (Homo sapiens (Human))	BDBM50108157 (CHEMBL75139 | N-[2-[4-(4-Chloro-phenoxy)-benzenesu...) Show SMILES CN1C(=O)N(CC(CS(=O)(=O)c2ccc(Oc3ccc(Cl)cc3)cc2)N(O)C=O)C(=O)C1(C)C Show InChI InChI=1S/C22H24ClN3O7S/c1-22(2)20(28)25(21(29)24(22)3)12-16(26(30)14-27)13-34(31,32)19-10-8-18(9-11-19)33-17-6-4-15(23)5-7-17/h4-11,14,16,30H,12-13H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	280	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro selective inhibition against matrix metalloprotease-1 (MMP-1) using a fluorimetric assay				J Med Chem 45: 219-32 (2001) BindingDB Entry DOI: 10.7270/Q2XP747B
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50108157 (CHEMBL75139 | N-[2-[4-(4-Chloro-phenoxy)-benzenesu...) Show SMILES CN1C(=O)N(CC(CS(=O)(=O)c2ccc(Oc3ccc(Cl)cc3)cc2)N(O)C=O)C(=O)C1(C)C Show InChI InChI=1S/C22H24ClN3O7S/c1-22(2)20(28)25(21(29)24(22)3)12-16(26(30)14-27)13-34(31,32)19-10-8-18(9-11-19)33-17-6-4-15(23)5-7-17/h4-11,14,16,30H,12-13H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	0.720	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro selective inhibition against matrix metalloprotease-2 (MMP-2) using fluorimetric assay				J Med Chem 45: 219-32 (2001) BindingDB Entry DOI: 10.7270/Q2XP747B
					More data for this Ligand-Target Pair