BDBM50108770 CHEMBL3596635

SMILES: CN(C(=O)c1c(F)cccc1Cl)c1ncc(cc1OCC1CCC1)-c1cc(ccc1Cl)C(N)=O

InChI Key: InChIKey=RAMLPYNWCNCHRY-UHFFFAOYSA-N

Data: 2 IC50  2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50108770   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human))	BDBM50108770 (CHEMBL3596635) Show SMILES CN(C(=O)c1c(F)cccc1Cl)c1ncc(cc1OCC1CCC1)-c1cc(ccc1Cl)C(N)=O Show InChI InChI=1S/C25H22Cl2FN3O3/c1-31(25(33)22-19(27)6-3-7-20(22)28)24-21(34-13-14-4-2-5-14)11-16(12-30-24)17-10-15(23(29)32)8-9-18(17)26/h3,6-12,14H,2,4-5,13H2,1H3,(H2,29,32)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Biogen Idec Inc. Curated by ChEMBL					Assay Description Inverse agonist activity at human recombinant GST-tagged RORgammat ligand binding domain assessed as effect on receptor-biotin tagged TRAP220 co-acti...				Bioorg Med Chem Lett 25: 2991-7 (2015) BindingDB Entry DOI: 10.7270/Q2ZP47XQ
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human))	BDBM50108770 (CHEMBL3596635) Show SMILES CN(C(=O)c1c(F)cccc1Cl)c1ncc(cc1OCC1CCC1)-c1cc(ccc1Cl)C(N)=O Show InChI InChI=1S/C25H22Cl2FN3O3/c1-31(25(33)22-19(27)6-3-7-20(22)28)24-21(34-13-14-4-2-5-14)11-16(12-30-24)17-10-15(23(29)32)8-9-18(17)26/h3,6-12,14H,2,4-5,13H2,1H3,(H2,29,32)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	n/a	n/a	60	n/a	n/a	n/a	n/a
Biogen Idec Inc. Curated by ChEMBL					Assay Description Inverse agonist activity at Gal4 DNA binding domain-tagged human RORgammat expressed in HEK293T cells assessed as effect on receptor-mediated transcr...				Bioorg Med Chem Lett 25: 2991-7 (2015) BindingDB Entry DOI: 10.7270/Q2ZP47XQ
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human))	BDBM50108770 (CHEMBL3596635) Show SMILES CN(C(=O)c1c(F)cccc1Cl)c1ncc(cc1OCC1CCC1)-c1cc(ccc1Cl)C(N)=O Show InChI InChI=1S/C25H22Cl2FN3O3/c1-31(25(33)22-19(27)6-3-7-20(22)28)24-21(34-13-14-4-2-5-14)11-16(12-30-24)17-10-15(23(29)32)8-9-18(17)26/h3,6-12,14H,2,4-5,13H2,1H3,(H2,29,32)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	n/a	n/a	58	n/a	n/a	n/a	n/a
Biogen Idec Inc. Curated by ChEMBL					Assay Description Inverse agonist activity at Gal4 DNA binding domain-tagged human RORgammat expressed in HEK293T cells assessed as effect on receptor-mediated transcr...				Bioorg Med Chem Lett 25: 2991-7 (2015) BindingDB Entry DOI: 10.7270/Q2ZP47XQ
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human))	BDBM50108770 (CHEMBL3596635) Show SMILES CN(C(=O)c1c(F)cccc1Cl)c1ncc(cc1OCC1CCC1)-c1cc(ccc1Cl)C(N)=O Show InChI InChI=1S/C25H22Cl2FN3O3/c1-31(25(33)22-19(27)6-3-7-20(22)28)24-21(34-13-14-4-2-5-14)11-16(12-30-24)17-10-15(23(29)32)8-9-18(17)26/h3,6-12,14H,2,4-5,13H2,1H3,(H2,29,32)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Biogen Idec Inc. Curated by ChEMBL					Assay Description Inverse agonist activity at human recombinant GST-tagged RORgammat ligand binding domain assessed as effect on receptor-biotin tagged TRAP220 co-acti...				Bioorg Med Chem Lett 25: 2991-7 (2015) BindingDB Entry DOI: 10.7270/Q2ZP47XQ
					More data for this Ligand-Target Pair