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SMILES: Fc1ccc(NC(=O)c2n[nH]c(c2C(F)(F)F)C(F)(F)F)c(Cl)c1

InChI Key: InChIKey=NSLGSSNRJNMZDV-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50109648   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Polyunsaturated fatty acid lipoxygenase ALOX15


(Homo sapiens (Human))		BDBM50109648
PNG
(CHEMBL3604161)
Show SMILES Fc1ccc(NC(=O)c2n[nH]c(c2C(F)(F)F)C(F)(F)F)c(Cl)c1
Show InChI InChI=1S/C12H5ClF7N3O/c13-5-3-4(14)1-2-6(5)21-10(24)8-7(11(15,16)17)9(23-22-8)12(18,19)20/h1-3H,(H,21,24)(H,22,23)
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PubMed
n/an/a 279n/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of 15-LOX-1 in human L1236 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before arachidonic...

Bioorg Med Chem Lett 25: 3024-9 (2015)


BindingDB Entry DOI: 10.7270/Q2R21350
More data for this
Ligand-Target Pair