BDBM50109653 2-Amino-3-[3-hydroxy-4-(4-hydroxy-phenyl)-isoxazol-5-yl]-propionic acid::CHEMBL367027

SMILES: N[C@@H](Cc1o[nH]c(=O)c1-c1ccc(O)cc1)C(O)=O

InChI Key: InChIKey=AWHJMTINWUANCP-QMMMGPOBSA-N

Data: 4 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50109653   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50109653 (2-Amino-3-[3-hydroxy-4-(4-hydroxy-phenyl)-isoxazol...) Show SMILES N[C@@H](Cc1o[nH]c(=O)c1-c1ccc(O)cc1)C(O)=O Show InChI InChI=1S/C12H12N2O5/c13-8(12(17)18)5-9-10(11(16)14-19-9)6-1-3-7(15)4-2-6/h1-4,8,15H,5,13H2,(H,14,16)(H,17,18)/t8-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	6.50E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description The compound was tested for the receptor binding affinity at Metabotropic glutamate receptor 5 using established second messenger assay systems.				J Med Chem 45: 988-91 (2002) BindingDB Entry DOI: 10.7270/Q2M32V27
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50109653 (2-Amino-3-[3-hydroxy-4-(4-hydroxy-phenyl)-isoxazol...) Show SMILES N[C@@H](Cc1o[nH]c(=O)c1-c1ccc(O)cc1)C(O)=O Show InChI InChI=1S/C12H12N2O5/c13-8(12(17)18)5-9-10(11(16)14-19-9)6-1-3-7(15)4-2-6/h1-4,8,15H,5,13H2,(H,14,16)(H,17,18)/t8-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	7.10E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description The compound was tested for the receptor binding affinity at Metabotropic glutamate receptor 1 using established second messenger assay systems.				J Med Chem 45: 988-91 (2002) BindingDB Entry DOI: 10.7270/Q2M32V27
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat))	BDBM50109653 (2-Amino-3-[3-hydroxy-4-(4-hydroxy-phenyl)-isoxazol...) Show SMILES N[C@@H](Cc1o[nH]c(=O)c1-c1ccc(O)cc1)C(O)=O Show InChI InChI=1S/C12H12N2O5/c13-8(12(17)18)5-9-10(11(16)14-19-9)6-1-3-7(15)4-2-6/h1-4,8,15H,5,13H2,(H,14,16)(H,17,18)/t8-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description The compound was tested for the receptor binding affinity at Metabotropic glutamate receptor 4 using established second messenger assay systems.				J Med Chem 45: 988-91 (2002) BindingDB Entry DOI: 10.7270/Q2M32V27
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50109653 (2-Amino-3-[3-hydroxy-4-(4-hydroxy-phenyl)-isoxazol...) Show SMILES N[C@@H](Cc1o[nH]c(=O)c1-c1ccc(O)cc1)C(O)=O Show InChI InChI=1S/C12H12N2O5/c13-8(12(17)18)5-9-10(11(16)14-19-9)6-1-3-7(15)4-2-6/h1-4,8,15H,5,13H2,(H,14,16)(H,17,18)/t8-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description The compound was tested for the receptor binding affinity at Metabotropic glutamate receptor 2 using established second messenger assay systems.				J Med Chem 45: 988-91 (2002) BindingDB Entry DOI: 10.7270/Q2M32V27
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1 (RAT)	BDBM50109653 (2-Amino-3-[3-hydroxy-4-(4-hydroxy-phenyl)-isoxazol...) Show SMILES N[C@@H](Cc1o[nH]c(=O)c1-c1ccc(O)cc1)C(O)=O Show InChI InChI=1S/C12H12N2O5/c13-8(12(17)18)5-9-10(11(16)14-19-9)6-1-3-7(15)4-2-6/h1-4,8,15H,5,13H2,(H,14,16)(H,17,18)/t8-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Concentration of the compound which causes 50% reduction in receptor binding affinity against Ionotropic glutamate receptor ionotropic kainate using ...				J Med Chem 45: 988-91 (2002) BindingDB Entry DOI: 10.7270/Q2M32V27
					More data for this Ligand-Target Pair