BDBM50109947 3-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-7-trimethylsilanyl-pyrazolo[1,5-a]pyridine::CHEMBL160454

SMILES: C[Si](C)(C)c1cccc2c(CN3CCN(CC3)c3ccc(Cl)cc3)cnn12

InChI Key: InChIKey=VLCYCTQMMKCUDI-UHFFFAOYSA-N

Data: 5 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50109947   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
D(4) dopamine receptor (Homo sapiens (Human))	BDBM50109947 (3-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-7-tri...) Show SMILES C[Si](C)(C)c1cccc2c(CN3CCN(CC3)c3ccc(Cl)cc3)cnn12 Show InChI InChI=1S/C21H27ClN4Si/c1-27(2,3)21-6-4-5-20-17(15-23-26(20)21)16-24-11-13-25(14-12-24)19-9-7-18(22)8-10-19/h4-10,15H,11-14,16H2,1-3H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	2.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description In vitro binding affinity at human cloned dopamine receptor D4 stably expressed in CHO cells by [3H]spiperone displacement.				Bioorg Med Chem Lett 12: 633-6 (2002) BindingDB Entry DOI: 10.7270/Q2JM2B5X
					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50109947 (3-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-7-tri...) Show SMILES C[Si](C)(C)c1cccc2c(CN3CCN(CC3)c3ccc(Cl)cc3)cnn12 Show InChI InChI=1S/C21H27ClN4Si/c1-27(2,3)21-6-4-5-20-17(15-23-26(20)21)16-24-11-13-25(14-12-24)19-9-7-18(22)8-10-19/h4-10,15H,11-14,16H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description In vitro binding affinity at human cloned dopamine receptor D3 stably expressed in CHO cells by [3H]spiperone displacement.				Bioorg Med Chem Lett 12: 633-6 (2002) BindingDB Entry DOI: 10.7270/Q2JM2B5X
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50109947 (3-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-7-tri...) Show SMILES C[Si](C)(C)c1cccc2c(CN3CCN(CC3)c3ccc(Cl)cc3)cnn12 Show InChI InChI=1S/C21H27ClN4Si/c1-27(2,3)21-6-4-5-20-17(15-23-26(20)21)16-24-11-13-25(14-12-24)19-9-7-18(22)8-10-19/h4-10,15H,11-14,16H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description In vitro binding affinity at human cloned dopamine receptor D2 (long) stably expressed in CHO cells by [3H]-Spiperone displacement.				Bioorg Med Chem Lett 12: 633-6 (2002) BindingDB Entry DOI: 10.7270/Q2JM2B5X
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50109947 (3-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-7-tri...) Show SMILES C[Si](C)(C)c1cccc2c(CN3CCN(CC3)c3ccc(Cl)cc3)cnn12 Show InChI InChI=1S/C21H27ClN4Si/c1-27(2,3)21-6-4-5-20-17(15-23-26(20)21)16-24-11-13-25(14-12-24)19-9-7-18(22)8-10-19/h4-10,15H,11-14,16H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description In vitro binding affinity at human cloned dopamine receptor D2 (long) stably expressed in CHO cells by [3H]-Spiperone displacement.				Bioorg Med Chem Lett 12: 633-6 (2002) BindingDB Entry DOI: 10.7270/Q2JM2B5X
					More data for this Ligand-Target Pair
DRD1 (BOVINE)	BDBM50109947 (3-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-7-tri...) Show SMILES C[Si](C)(C)c1cccc2c(CN3CCN(CC3)c3ccc(Cl)cc3)cnn12 Show InChI InChI=1S/C21H27ClN4Si/c1-27(2,3)21-6-4-5-20-17(15-23-26(20)21)16-24-11-13-25(14-12-24)19-9-7-18(22)8-10-19/h4-10,15H,11-14,16H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	7.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.				Bioorg Med Chem Lett 12: 633-6 (2002) BindingDB Entry DOI: 10.7270/Q2JM2B5X
					More data for this Ligand-Target Pair