BDBM50110166 CHEMBL2218680

SMILES: FC(F)(F)c1cccc(C(=O)N2CCn3c(C2)nnc3-c2ccccn2)c1Cl

InChI Key: InChIKey=QFABBPVMYKHOQR-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50110166   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
P2X purinoceptor 7 (P2X7) (Rattus norvegicus (Rat))	BDBM50110166 (CHEMBL2218680) Show SMILES FC(F)(F)c1cccc(C(=O)N2CCn3c(C2)nnc3-c2ccccn2)c1Cl Show InChI InChI=1S/C18H13ClF3N5O/c19-15-11(4-3-5-12(15)18(20,21)22)17(28)26-8-9-27-14(10-26)24-25-16(27)13-6-1-2-7-23-13/h1-7H,8-10H2	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.31E+3	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutical Research& Development L.L.C. Curated by ChEMBL					Assay Description Antagonist activity at rat P2X7 receptor assessed as inhibition of ATP-induced Ca2+ flux by FLIPR assay				Bioorg Med Chem Lett 25: 3157-63 (2015) BindingDB Entry DOI: 10.7270/Q2BV7JD0
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50110166 (CHEMBL2218680) Show SMILES FC(F)(F)c1cccc(C(=O)N2CCn3c(C2)nnc3-c2ccccn2)c1Cl Show InChI InChI=1S/C18H13ClF3N5O/c19-15-11(4-3-5-12(15)18(20,21)22)17(28)26-8-9-27-14(10-26)24-25-16(27)13-6-1-2-7-23-13/h1-7H,8-10H2	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	9.70	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutical Research& Development L.L.C. Curated by ChEMBL					Assay Description Antagonist activity at human recombinant P2X7 receptor expressed in human 1321N1 cells assessed as inhibition of BzATP-induced Ca2+ flux after 30 min...				Bioorg Med Chem Lett 25: 3157-63 (2015) BindingDB Entry DOI: 10.7270/Q2BV7JD0
					More data for this Ligand-Target Pair