BDBM50111274 8-(4-(1-(4-chlorophenyl)-4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrole-3-carboxamido)phenoxy)octanoic acid::8-(4-{[1-(4-Chloro-phenyl)-4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrole-3-carbonyl]-amino}-phenoxy)-octanoic acid::CHEMBL10213
SMILES: OC(=O)CCCCCCCOc1ccc(NC(=O)C2C(=O)CN(C2=O)c2ccc(Cl)cc2)cc1
InChI Key: InChIKey=VNHAIWMQUUZVKP-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Plasminogen activator inhibitor-1 (Homo sapiens (Human)) | BDBM50111274 (8-(4-(1-(4-chlorophenyl)-4-hydroxy-2-oxo-2,5-dihyd...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bayreuth Curated by ChEMBL | Assay Description Inhibition of PAI1 | Bioorg Med Chem 16: 4203-21 (2008) Article DOI: 10.1016/j.bmc.2008.02.069 BindingDB Entry DOI: 10.7270/Q2C24W6P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor-1 (Homo sapiens (Human)) | BDBM50111274 (8-(4-(1-(4-chlorophenyl)-4-hydroxy-2-oxo-2,5-dihyd...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenova Limited Curated by ChEMBL | Assay Description Inhibitory activity against human plasminogen activator inhibitor-1(PAI-1) evaluated by chromogenic assay. | Bioorg Med Chem Lett 12: 1063-6 (2002) BindingDB Entry DOI: 10.7270/Q2W958HQ | |||||||||||
More data for this Ligand-Target Pair |